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Literature DB >> 3163799

Adenosine deaminase gene expression is regulated posttranscriptionally in the nucleus.

T M Berkvens¹, F Schoute, H van Ormondt, P Meera Khan, A J van der Eb.

Abstract

The housekeeping enzyme adenosine deaminase (ADA) shows a large variation in tissue-specific expression ranging from 1 Iu in red blood cells to 880 Iu in thymocytes. We investigated the acute lymphocytic leukemic cell line Molt-4 (660 Iu ADA/g protein) and the promyelocytic cell line HL-60 (38 Iu ADA/g protein) as a model system to determine the levels at which the tissue-specific expression of ADA is regulated. From our results it can be concluded that the almost 20-fold difference in ADA expression between Molt-4 and HL-60 is the result of differences in the post-transcriptional processing and/or stability of ADA pre-mRNA within the nucleus.

Entities: Disease Gene

Mesh：

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Year: 1988 PMID： 3163799 PMCID： PMC336492 DOI： 10.1093/nar/16.8.3255

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

40 in total

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5. Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors.

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Journal: Cell Date: 1985-09 Impact factor: 41.582

6. Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency.

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Authors: D Valerio; M G Duyvesteyn; A J van der Eb
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8. Cloning of human adenosine deaminase cDNA and expression in mouse cells.

Authors: D Valerio; R S McIvor; S R Williams; M G Duyvesteyn; H van Ormondt; A J van der Eb; D W Martin
Journal: Gene Date: 1984-11 Impact factor: 3.688

9. Post-transcriptional control of myc and p53 expression during differentiation of the embryonal carcinoma cell line F9.

Authors: C Dony; M Kessel; P Gruss
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10. One adenosine deaminase allele in a patient with severe combined immunodeficiency contains a point mutation abolishing enzyme activity.

Authors: D Valerio; B M Dekker; M G Duyvesteyn; L van der Voorn; T M Berkvens; H van Ormondt; A J van der Eb
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4 in total

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2. Cell type-specific mechanisms of regulating expression of the ornithine decarboxylase gene after growth stimulation.

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3. Alterations in adenosine metabolism and signaling in patients with chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

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Journal: PLoS One Date: 2010-02-16 Impact factor: 3.240

4. Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype.

Authors: I Santisteban; F X Arredondo-Vega; S Kelly; A Mary; A Fischer; D S Hummell; A Lawton; R U Sorensen; E R Stiehm; L Uribe
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4 in total