Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 IFITM3/STAT3 axis promotes glioma cells invasion and is modulated by TGF-β.

Literature DB >> 31637620

IFITM3/STAT3 axis promotes glioma cells invasion and is modulated by TGF-β.

Hongliang Wang^1,2, Feng Tang^1,2, Erbao Bian^1,2, Yile Zhang^1,2, Xinghu Ji^1,2, Zhihao Yang^1,2, Bing Zhao^3,4.

Abstract

Glioma is the most aggressive primary brain tumor. We have previously provided evidence that IFITM3 promoted glioma cells migration. However, the mechanism of how IFITM3 regulates glioma cells invasion and whether IFITM3 participates in TGF-β-mediated glioma invasion are still unknown. In this paper, we proved that IFITM3 was notably up-regulated in glioma tissues. Knockdown of IFITM3 suppressed STAT3 phosphorylation in vitro, and a specific STAT3 inhibitor AG490 reversed IFITM3-induced invasion of glioma cells. Furthermore, IFITM3 expression was induced by TGF-β in glioma and IFITM3 knockdown abolished TGF-β-mediated glioma cells invasion. Collectively, the results indicate that IFITM3/STAT3 axis may promote TGF-β-induced glioma cells invasion. This study provided some suggestions for the clinical treatment of the brain tumor.

Entities: Disease Gene

Keywords: Glioma; IFITM3; Invasion; STAT3; TGF-β

Mesh：

Substances：

Year: 2019 PMID： 31637620 DOI： 10.1007/s11033-019-05146-2

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

49 in total

1. Dioscin suppresses TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration and invasion.

Authors: Won-Chul Lim; Hyunhee Kim; Young-Joo Kim; Kyung-Chul Choi; In Ho Lee; Ki Heon Lee; Mi Kyung Kim; Hyeonseok Ko
Journal: Bioorg Med Chem Lett Date: 2017-06-03 Impact factor: 2.823

Review 2. STATs and gene regulation.

Authors: J E Darnell
Journal: Science Date: 1997-09-12 Impact factor: 47.728

3. Activation of STAT3 is a marker of poor prognosis in human colorectal cancer.

Authors: Takafumi Kusaba; Toshiyuki Nakayama; Kazuyuki Yamazumi; Yuichi Yakata; Ayumi Yoshizaki; Kenichiro Inoue; Takeshi Nagayasu; Ichiro Sekine
Journal: Oncol Rep Date: 2006-06 Impact factor: 3.906

4. [Interferon-induced transmembrane protein 3 knock-down inhibits proliferation and invasion of hepatocellular carcinoma HepG2 cells in vitro].

Authors: Rong-Shou Wu; Lin-Quan Wu; Ke-Hao Li; En-Liang Li; Qian Feng; Jing-Ling Zhang
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2016-02

Review 5. Targeting transcription factor STAT3 for cancer prevention and therapy.

Authors: Edna Zhi Pei Chai; Muthu K Shanmugam; Frank Arfuso; Arunasalam Dharmarajan; Chao Wang; Alan Prem Kumar; Ramar Perumal Samy; Lina H K Lim; Lingzhi Wang; Boon Cher Goh; Kwang Seok Ahn; Kam Man Hui; Gautam Sethi
Journal: Pharmacol Ther Date: 2016-02-12 Impact factor: 12.310

6. JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells.

Authors: Reng-Yun Liu; Yuanyuan Zeng; Zhe Lei; Longqiang Wang; Haiping Yang; Zeyi Liu; Jun Zhao; Hong-Tao Zhang
Journal: Int J Oncol Date: 2014-02-21 Impact factor: 5.650

Review 7. Transforming growth factor (TGF)-β expression and activation mechanisms as potential targets for anti-tumor therapy and tumor imaging.

Authors: Marlous Arjaans; Thijs H Oude Munnink; Hetty Timmer-Bosscha; Michael Reiss; Annemiek M E Walenkamp; Marjolijn N Lub-de Hooge; Elisabeth G E de Vries; Carolina P Schröder
Journal: Pharmacol Ther Date: 2012-05-12 Impact factor: 12.310

8. Ifitm3 limits the severity of acute influenza in mice.

Authors: Charles C Bailey; I-Chueh Huang; Christina Kam; Michael Farzan
Journal: PLoS Pathog Date: 2012-09-06 Impact factor: 6.823

9. The role of IFITM3 in the growth and migration of human glioma cells.

Authors: Bing Zhao; Hongliang Wang; Gang Zong; Ping Li
Journal: BMC Neurol Date: 2013-12-27 Impact factor: 2.474

10. Overexpression of IFITM3 predicts poor prognosis in stage IIA esophageal squamous cell carcinoma after Ivor Lewis esophagectomy.

Authors: Yang Jia; Zhaohua Xiao; Wenpeng Jiang; Gang Chen; Zhou Wang
Journal: Thorac Cancer Date: 2017-08-30 Impact factor: 3.500

9 in total

1. Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.

Authors: Nicholas A Vitanza; Matt C Biery; Carrie Myers; Eric Ferguson; Ye Zheng; Emily J Girard; Justyna M Przystal; Giulia Park; Alyssa Noll; Fiona Pakiam; Conrad A Winter; Shelli M Morris; Jay Sarthy; Bonnie L Cole; Sarah E S Leary; Courtney Crane; Nicole A P Lieberman; Sabine Mueller; Javad Nazarian; Raphael Gottardo; Mi-Youn Brusniak; Andrew J Mhyre; James M Olson
Journal: Neuro Oncol Date: 2021-03-25 Impact factor: 12.300

2. Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors.

Authors: Yun Cai; Wenfei Ji; Chuan Sun; Rui Xu; Xuechun Chen; Yifan Deng; Jiadong Pan; Jiayue Yang; Hongjun Zhu; Jie Mei
Journal: Front Immunol Date: 2021-08-11 Impact factor: 7.561

3. Normal Basal Epithelial Cells Stimulate the Migration and Invasion of Prostate Cancer Cell RM-1 by TGF-β1/STAT3 Axis in vitro.

Authors: Chun-Yan Li; Chun-Ya Chen; Jian-Hong An; Jian-Bin Wu; Hong Shen
Journal: Cancer Manag Res Date: 2021-05-07 Impact factor: 3.989