| Literature DB >> 26478441 |
Edna Zhi Pei Chai1, Muthu K Shanmugam1, Frank Arfuso2, Arunasalam Dharmarajan2, Chao Wang3, Alan Prem Kumar4, Ramar Perumal Samy5, Lina H K Lim5, Lingzhi Wang3, Boon Cher Goh6, Kwang Seok Ahn7, Kam Man Hui8, Gautam Sethi9.
Abstract
Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.Entities:
Keywords: Angiogenesis; Apoptosis; Cancer; Cytokines; Proliferation; STAT3
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Year: 2016 PMID： 26478441 DOI： 10.1016/j.pharmthera.2015.10.004
Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310