Literature DB >> 31633864

The fog of genetics: what is known, unknown and unknowable in the genetics of complex traits and diseases.

João Pedro de Magalhães1, Jingwei Wang1,2.   

Abstract

A major task for genetics is searching for genetic variants associated with disease. But we may well be missing a large number of "unknown unknown" alleles in the "fog of genetics".
© 2019 The Authors.

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Year:  2019        PMID： 31633864      PMCID： PMC6831998          DOI： 10.15252/embr.201948054

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  11 in total

1.  Clan genomics and the complex architecture of human disease.

Authors:  James R Lupski; John W Belmont; Eric Boerwinkle; Richard A Gibbs
Journal:  Cell       Date:  2011-09-30       Impact factor: 41.582

2.  Genetic heterogeneity in human disease.

Authors:  Jon McClellan; Mary-Claire King
Journal:  Cell       Date:  2010-04-16       Impact factor: 41.582

3.  The support of human genetic evidence for approved drug indications.

Authors:  Matthew R Nelson; Hannah Tipney; Jeffery L Painter; Judong Shen; Paola Nicoletti; Yufeng Shen; Aris Floratos; Pak Chung Sham; Mulin Jun Li; Junwen Wang; Lon R Cardon; John C Whittaker; Philippe Sanseau
Journal:  Nat Genet       Date:  2015-06-29       Impact factor: 38.330

Review 4.  An Expanded View of Complex Traits: From Polygenic to Omnigenic.

Authors:  Evan A Boyle; Yang I Li; Jonathan K Pritchard
Journal:  Cell       Date:  2017-06-15       Impact factor: 41.582

5.  An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people.

Authors:  Matthew R Nelson; Daniel Wegmann; Margaret G Ehm; Darren Kessner; Pamela St Jean; Claudio Verzilli; Judong Shen; Zhengzheng Tang; Silviu-Alin Bacanu; Dana Fraser; Liling Warren; Jennifer Aponte; Matthew Zawistowski; Xiao Liu; Hao Zhang; Yong Zhang; Jun Li; Yun Li; Li Li; Peter Woollard; Simon Topp; Matthew D Hall; Keith Nangle; Jun Wang; Gonçalo Abecasis; Lon R Cardon; Sebastian Zöllner; John C Whittaker; Stephanie L Chissoe; John Novembre; Vincent Mooser
Journal:  Science       Date:  2012-05-17       Impact factor: 47.728

6.  The fog of genetics: what is known, unknown and unknowable in the genetics of complex traits and diseases.

Authors:  João Pedro de Magalhães; Jingwei Wang
Journal:  EMBO Rep       Date:  2019-10-21       Impact factor: 8.807

7.  Disease networks. Uncovering disease-disease relationships through the incomplete interactome.

Authors:  Jörg Menche; Amitabh Sharma; Maksim Kitsak; Susan Dina Ghiassian; Marc Vidal; Joseph Loscalzo; Albert-László Barabási
Journal:  Science       Date:  2015-02-20       Impact factor: 47.728

8.  Microbial evolution. Global epistasis makes adaptation predictable despite sequence-level stochasticity.

Authors:  Sergey Kryazhimskiy; Daniel P Rice; Elizabeth R Jerison; Michael M Desai
Journal:  Science       Date:  2014-06-27       Impact factor: 47.728

Review 9.  Genetic architecture: the shape of the genetic contribution to human traits and disease.

Authors:  Nicholas J Timpson; Celia M T Greenwood; Nicole Soranzo; Daniel J Lawson; J Brent Richards
Journal:  Nat Rev Genet       Date:  2017-12-11       Impact factor: 53.242

10.  Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis.

Authors:  Gerard Muntané; Xavier Farré; Juan Antonio Rodríguez; Cinta Pegueroles; David A Hughes; João Pedro de Magalhães; Toni Gabaldón; Arcadi Navarro
Journal:  Mol Biol Evol       Date:  2018-08-01       Impact factor: 16.240
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  4 in total

1.  The fog of genetics: what is known, unknown and unknowable in the genetics of complex traits and diseases.

Authors:  João Pedro de Magalhães; Jingwei Wang
Journal:  EMBO Rep       Date:  2019-10-21       Impact factor: 8.807

2.  Genomic Variation, Evolvability, and the Paradox of Mental Illness.

Authors:  Camillo Thomas Gualtieri
Journal:  Front Psychiatry       Date:  2021-01-21       Impact factor: 4.157

3.  Gene Size Matters: An Analysis of Gene Length in the Human Genome.

Authors:  Inês Lopes; Gulam Altab; Priyanka Raina; João Pedro de Magalhães
Journal:  Front Genet       Date:  2021-02-11       Impact factor: 4.599

4.  Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span.

Authors:  Xavier Farré; Ruben Molina; Fabio Barteri; Paul R H J Timmers; Peter K Joshi; Baldomero Oliva; Sandra Acosta; Borja Esteve-Altava; Arcadi Navarro; Gerard Muntané
Journal:  Mol Biol Evol       Date:  2021-10-27       Impact factor: 16.240
  4 in total

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