Literature DB >> 31633196

To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy.

Benjamin Heyman1, Catriona Jamieson1.   

Abstract

A new study reveals that leukemia stem cells (LSCs) in acute myeloid leukemia downregulate natural killer cell-activating receptor ligands to evade immune surveillance via the transcriptional co-factor PARP1. The inhibition of PARP1 sensitizes LSCs to immunotherapy, highlighting its potential as a therapeutic target.
© 2019 The Authors.

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Year:  2019        PMID： 31633196      PMCID： PMC6826187          DOI： 10.15252/embj.2019103479

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  12 in total

1.  Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia.

Authors:  Jean-Pierre Issa; Guillermo Garcia-Manero; Xuelin Huang; Jorge Cortes; Farhad Ravandi; Elias Jabbour; Gautam Borthakur; Mark Brandt; Sherry Pierce; Hagop M Kantarjian
Journal:  Cancer       Date:  2014-10-21       Impact factor: 6.860

2.  A 17-gene stemness score for rapid determination of risk in acute leukaemia.

Authors:  Stanley W K Ng; Amanda Mitchell; James A Kennedy; Weihsu C Chen; Jessica McLeod; Narmin Ibrahimova; Andrea Arruda; Andreea Popescu; Vikas Gupta; Aaron D Schimmer; Andre C Schuh; Karen W Yee; Lars Bullinger; Tobias Herold; Dennis Görlich; Thomas Büchner; Wolfgang Hiddemann; Wolfgang E Berdel; Bernhard Wörmann; Meyling Cheok; Claude Preudhomme; Herve Dombret; Klaus Metzeler; Christian Buske; Bob Löwenberg; Peter J M Valk; Peter W Zandstra; Mark D Minden; John E Dick; Jean C Y Wang
Journal:  Nature       Date:  2016-12-07       Impact factor: 49.962

3.  Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses.

Authors:  Julia Hilpert; Ludger Grosse-Hovest; Frank Grünebach; Corina Buechele; Tina Nuebling; Tobias Raum; Alexander Steinle; Helmut Rainer Salih
Journal:  J Immunol       Date:  2012-06-22       Impact factor: 5.422

4.  Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Authors:  Daniel A Pollyea; Brett M Stevens; Courtney L Jones; Amanda Winters; Shanshan Pei; Mohammad Minhajuddin; Angelo D'Alessandro; Rachel Culp-Hill; Kent A Riemondy; Austin E Gillen; Jay R Hesselberth; Diana Abbott; Derek Schatz; Jonathan A Gutman; Enkhtsetseg Purev; Clayton Smith; Craig T Jordan
Journal:  Nat Med       Date:  2018-11-12       Impact factor: 53.440

5.  To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy.

Authors:  Benjamin Heyman; Catriona Jamieson
Journal:  EMBO J       Date:  2019-10-21       Impact factor: 11.598

6.  Tracing the origins of relapse in acute myeloid leukaemia to stem cells.

Authors:  Liran I Shlush; Amanda Mitchell; Lawrence Heisler; Sagi Abelson; Stanley W K Ng; Aaron Trotman-Grant; Jessie J F Medeiros; Abilasha Rao-Bhatia; Ivana Jaciw-Zurakowsky; Rene Marke; Jessica L McLeod; Monica Doedens; Gary Bader; Veronique Voisin; ChangJiang Xu; John D McPherson; Thomas J Hudson; Jean C Y Wang; Mark D Minden; John E Dick
Journal:  Nature       Date:  2017-06-28       Impact factor: 49.962

7.  Opposing effect of IFNgamma and IFNalpha on expression of NKG2 receptors: negative regulation of IFNgamma on NK cells.

Authors:  Cai Zhang; Jian Zhang; Rui Sun; Jinbo Feng; Haiming Wei; Zhigang Tian
Journal:  Int Immunopharmacol       Date:  2005-06       Impact factor: 4.932

8.  Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion.

Authors:  Anna M Paczulla; Kathrin Rothfelder; Simon Raffel; Martina Konantz; Julia Steinbacher; Hui Wang; Claudia Tandler; Marcelle Mbarga; Thorsten Schaefer; Mattia Falcone; Eva Nievergall; Daniela Dörfel; Pauline Hanns; Jakob R Passweg; Christoph Lutz; Juerg Schwaller; Robert Zeiser; Bruce R Blazar; Michael A Caligiuri; Stephan Dirnhofer; Pontus Lundberg; Lothar Kanz; Leticia Quintanilla-Martinez; Alexander Steinle; Andreas Trumpp; Helmut R Salih; Claudia Lengerke
Journal:  Nature       Date:  2019-07-17       Impact factor: 49.962

9.  Interleukin-15 enhances natural killer cell cytotoxicity in patients with acute myeloid leukemia by upregulating the activating NK cell receptors.

Authors:  Miroslaw J Szczepanski; Marta Szajnik; Ann Welsh; Kenneth A Foon; Theresa L Whiteside; Michael Boyiadzis
Journal:  Cancer Immunol Immunother       Date:  2009-06-13       Impact factor: 6.968

10.  Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome.

Authors:  Emmanuel Raffoux; Audrey Cras; Christian Recher; Pierre-Yves Boëlle; Adrienne de Labarthe; Pascal Turlure; Jean-Pierre Marolleau; Oumedaly Reman; Claude Gardin; Maud Victor; Sébastien Maury; Philippe Rousselot; Jean-Valère Malfuson; Odile Maarek; Marie-Thérèse Daniel; Pierre Fenaux; Laurent Degos; Christine Chomienne; Sylvie Chevret; Hervé Dombret
Journal:  Oncotarget       Date:  2010-05
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  4 in total

1.  To PARP or not to PARP?-Toward sensitizing acute myeloid leukemia stem cells to immunotherapy.

Authors:  Benjamin Heyman; Catriona Jamieson
Journal:  EMBO J       Date:  2019-10-21       Impact factor: 11.598

2.  Up-Regulation of PARP1 Expression Significantly Correlated with Poor Survival in Mucosal Melanomas.

Authors:  Piotr Donizy; Cheng-Lin Wu; Jason Mull; Masakazu Fujimoto; Agata Chłopik; Yan Peng; Sara C Shalin; M Angelica Selim; Susana Puig; Maria-Teresa Fernandez-Figueras; Christopher R Shea; Wojciech Biernat; Janusz Ryś; Andrzej Marszalek; Mai P Hoang
Journal:  Cells       Date:  2020-05-05       Impact factor: 6.600

Review 3.  Mechanism research and treatment progress of NAD pathway related molecules in tumor immune microenvironment.

Authors:  QinChen Xu; Xiaoyan Liu; Ghazal Mohseni; Xiaodong Hao; Yidan Ren; Yiwei Xu; Huiru Gao; Qin Wang; Yunshan Wang
Journal:  Cancer Cell Int       Date:  2022-07-30       Impact factor: 6.429

4.  Long Non-Coding RNA LINC00152 Regulates Self-Renewal of Leukemia Stem Cells and Induces Chemo-Resistance in Acute Myeloid Leukemia.

Authors:  Chunhong Cui; Yan Wang; Wenjie Gong; Haiju He; Hao Zhang; Wei Shi; Hui Wang
Journal:  Front Oncol       Date:  2021-07-06       Impact factor: 6.244
  4 in total

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