Literature DB >> 31632576

m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation.

Jie Li1, Lijun Zhu1, Yanhong Shi1, Jingnan Liu1, Lin Lin1, Xi Chen1.   

Abstract

N6-methyladenosine (m6A) acts as the most common mRNA modification in mammal cells. Fat Mass and Obesity-associated protein (FTO) is the firstly identified demethylase in the m6A modification. This research tries to discover the potential roles of FTO in the m6A modification in the hepatocellular carcinoma (HCC). FTO level was found to be up-regulated in the HCC tissue and cells. The over-expression of FTO was correlated to the poor prognosis of HCC individuals. Knockdown of FTO suppressed the proliferation and in vivo tumor growth, and induced the G0/G1 phase arrest. Mechanically, FTO triggered the demethylation of PKM2 mRNA and accelerated the translated production. Overall, this finding suggests the critical function of FTO in the HCC oncogenesis and its m6A modification. AJTR
Copyright © 2019.

Entities:  

Keywords:  FTO; Hepatocellular carcinoma; N6-methyladenosine; PKM2

Year:  2019        PMID： 31632576      PMCID： PMC6789218     

Source DB:  PubMed          Journal:  Am J Transl Res            Impact factor:   4.060


  27 in total

1.  m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression.

Authors:  Jiqin Liu; Dangli Ren; Zhenhua Du; Hekong Wang; Hua Zhang; Ying Jin
Journal:  Biochem Biophys Res Commun       Date:  2018-06-02       Impact factor: 3.575

Review 2.  The Critical Role of RNA m6A Methylation in Cancer.

Authors:  Qing Lan; Pei Y Liu; Jacob Haase; Jessica L Bell; Stefan Hüttelmaier; Tao Liu
Journal:  Cancer Res       Date:  2019-03-20       Impact factor: 12.701

3.  RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.

Authors:  Mengnuo Chen; Lai Wei; Cheuk-Ting Law; Felice Ho-Ching Tsang; Jialing Shen; Carol Lai-Hung Cheng; Long-Hin Tsang; Daniel Wai-Hung Ho; David Kung-Chun Chiu; Joyce Man-Fong Lee; Carmen Chak-Lui Wong; Irene Oi-Lin Ng; Chun-Ming Wong
Journal:  Hepatology       Date:  2018-04-19       Impact factor: 17.425

4.  Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion.

Authors:  Zhenrui Li; Pengxu Qian; Wanqing Shao; Hailing Shi; Xi C He; Madelaine Gogol; Zulin Yu; Yongfu Wang; Meijie Qi; Yunfei Zhu; John M Perry; Kai Zhang; Fang Tao; Kun Zhou; Deqing Hu; Yingli Han; Chongbei Zhao; Richard Alexander; Hanzhang Xu; Shiyuan Chen; Allison Peak; Kathyrn Hall; Michael Peterson; Anoja Perera; Jeffrey S Haug; Tari Parmely; Hua Li; Bin Shen; Julia Zeitlinger; Chuan He; Linheng Li
Journal:  Cell Res       Date:  2018-07-31       Impact factor: 25.617

5.  MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein.

Authors:  Zhe Yang; Jiong Li; Guoxing Feng; Shan Gao; Yuan Wang; Shuqin Zhang; Yunxia Liu; Lihong Ye; Yueguo Li; Xiaodong Zhang
Journal:  J Biol Chem       Date:  2017-01-19       Impact factor: 5.157

6.  The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA.

Authors:  Jie Li; Yi Han; Hongmei Zhang; Zhe Qian; Wenyun Jia; Yuan Gao; Hua Zheng; Baolan Li
Journal:  Biochem Biophys Res Commun       Date:  2019-03-21       Impact factor: 3.575

Review 7.  Importance of m N6-methyladenosine (m6A) RNA modification in cancer.

Authors:  Gulten Tuncel; Rasime Kalkan
Journal:  Med Oncol       Date:  2019-03-16       Impact factor: 3.064

8.  HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.

Authors:  Qiuran Xu; Jianfeng Tu; Changwei Dou; Jun Zhang; Liu Yang; Xin Liu; Kefeng Lei; Zhikui Liu; Yufeng Wang; Lijie Li; Hangxing Bao; Jiahui Wang; Kangsheng Tu
Journal:  Mol Cancer       Date:  2017-12-20       Impact factor: 27.401

9.  High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma.

Authors:  Dong-Hui Lu; Wen-Wen Lv; Wen-Xing Li; Yue-Dong Gao
Journal:  Oncol Lett       Date:  2018-07-06       Impact factor: 2.967

10.  Hepatocellular carcinoma surveillance: Eastern and Western perspectives.

Authors:  Yvonne Purcell; Pauline Copin; Luisa Paulatto; Romain Pommier; Valérie Vilgrain; Maxime Ronot
Journal:  Ultrasonography       Date:  2018-10-28
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  54 in total

Review 1.  N6-methyladenine RNA modification and cancer.

Authors:  Jun Yang; Junwen Chen; Xiang Fei; Xia Wang; Kefeng Wang
Journal:  Oncol Lett       Date:  2020-06-16       Impact factor: 2.967

2.  RNA methylation regulators contribute to poor prognosis of hepatocellular carcinoma associated with the suppression of bile acid metabolism: a multi-omics analysis.

Authors:  Tao Zhang; Jian Gu; Xinyi Wang; Jiajia Luo; Jing Yan; Kailin Cai; Huili Li; Yingli Nie; Xiangdong Chen; Jiliang Wang
Journal:  Am J Cancer Res       Date:  2022-07-15       Impact factor: 5.942

Review 3.  Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application.

Authors:  Fusheng Zhang; Haiyang Liu; Meiqi Duan; Guang Wang; Zhenghou Zhang; Yutian Wang; Yiping Qian; Zhi Yang; Xiaofeng Jiang
Journal:  J Hematol Oncol       Date:  2022-07-06       Impact factor: 23.168

Review 4.  Advances in the functional roles of N6-methyladenosine modification in cancer progression: mechanisms and clinical implications.

Authors:  Peilin Chen; Jianhang Hu; Xiaodong Han; Yabing Chen
Journal:  Mol Biol Rep       Date:  2022-01-13       Impact factor: 2.742

Review 5.  Dairy consumption and hepatocellular carcinoma risk.

Authors:  Bodo C Melnik
Journal:  Ann Transl Med       Date:  2021-04

Review 6.  Role of m6A in osteoporosis, arthritis and osteosarcoma (Review).

Authors:  Yibo Hu; Xiaohui Zhao
Journal:  Exp Ther Med       Date:  2021-06-30       Impact factor: 2.447

Review 7.  The emerging roles of N6-methyladenosine RNA methylation in human cancers.

Authors:  Huafei Shen; Yifen Lan; Yanchun Zhao; Yuanfei Shi; Jie Jin; Wanzhuo Xie
Journal:  Biomark Res       Date:  2020-06-29

Review 8.  Function and clinical significance of N6-methyladenosine in digestive system tumours.

Authors:  Junchao Huang; Yingjie Shao; Wendong Gu
Journal:  Exp Hematol Oncol       Date:  2021-07-10

9.  Systematic analysis of molecular characterization and clinical relevance of m6A regulators in digestive system pan-cancers.

Authors:  Tiankuo Kou; Ruizhi Chai; Lan Jin; Zhigang Bai; Yun Yang; Yongtian Zhao; Dongfang Wu; Zhongtao Zhang; Yingchi Yang
Journal:  Exp Biol Med (Maywood)       Date:  2021-06-08

Review 10.  Mechanisms of RNA N6-Methyladenosine in Hepatocellular Carcinoma: From the Perspectives of Etiology.

Authors:  Jiahua Lu; Junjie Qian; Shengyong Yin; Lin Zhou; Shusen Zheng; Wu Zhang
Journal:  Front Oncol       Date:  2020-07-07       Impact factor: 6.244
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