| Literature DB >> 31629480 |
Abstract
A refined mesoscopic model for the cumulative effect of repulsive excluded volume protein-protein interaction and attractive protein-surface interaction upon the properties of a trace protein capable of fiber formation is presented. The model predicts that very small changes in the magnitude of bulk volume occupancy or the strength of protein-surface attraction may result in very large changes in the extent of trace protein fibrillation and the distribution of trace protein between bulk and adsorbed phases. Published by Elsevier Inc.Entities:
Year: 2019 PMID: 31629480 PMCID: PMC6838961 DOI: 10.1016/j.bpj.2019.09.033
Source DB: PubMed Journal: Biophys J ISSN: 0006-3495 Impact factor: 4.033