Matthew Donadu1, Donatella Usai2, Antonio Pinna3, Tiziana Porcu4, Vittorio Mazzarello5, Maura Fiamma6, Mauro Marchetti7, Sara Cannas8, Giovanni Delogu9, Stefania Zanetti10, Paola Molicotti11. 1. University of Sassari, Sassari, Italy. mdonadu@uniss.it. 2. University of Sassari, Sassari, Italy. dusai@uniss.it. 3. University of Sassari, Sassari, Italy. apinna@uniss.it. 4. University of Sassari, Sassari, Italy. tiziana.porcu@hotmail.it. 5. University of Sassari, Sassari, Italy. vmazza@uniss.it. 6. University of Sassari, Sassari, Italy. maurafiamma@yahoo.it. 7. CNR, Institute of Biomolecular Chemistry, Li Punti, Sassari, Italy. mauro@ss.cnr.it. 8. University of Sassari, Sassari, Italy. sarac1977@libero.it. 9. Sacro Cuore Catholic University, Rome, Italy. giovanni.delogu@unicatt.it. 10. University of Sassari, Sassari, Italy. zanettis@uniss.it. 11. University of Sassari, Sassari, Italy. molicott@uniss.it.
Abstract
INTRODUCTION: Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant, antiseptic, antifungal and antimicrobial properties. METHODOLOGY: in this study, the antimicrobial activity of two Lavender essential oils (Lavanda sumian and Lavanda grosso) against 16 multidrug-resistant P. aeruginosa strains from clinical ocular samples taken from migrant patients has been investigated. The in vitro cytotoxic activity on human Wong-Kilbourne derivative (WKD) conjunctiva cells from healthy patients and nitric oxide synthase (NOS) activity on murine macrophage (J774.1A) were also evaluated. RESULTS: L. sumian showed lower antimicrobial activity when compared to L. grosso. Both lavender oils tested had no cytotoxic effect at very low concentrations, mostly L. grosso. The essential oils extracted from L. sumian and L. grosso significantly reduced NOS in a cell model. CONCLUSION: Increase in drug resistance and lack of new antibiotics may encourage the development of natural antimicrobial treatments.
INTRODUCTION:Lavender is an evergreen shrub native to Northern Africa and other mountainous Mediterranean regions. It grows throughout Southern Europe, the United States, and Australia. Lavender essential oil has been used since ancient times and is known for its anti-inflammatory, antidepressant, antiseptic, antifungal and antimicrobial properties. METHODOLOGY: in this study, the antimicrobial activity of two Lavender essential oils (Lavanda sumian and Lavanda grosso) against 16 multidrug-resistant P. aeruginosa strains from clinical ocular samples taken from migrant patients has been investigated. The in vitro cytotoxic activity on humanWong-Kilbourne derivative (WKD) conjunctiva cells from healthy patients and nitric oxide synthase (NOS) activity on murine macrophage (J774.1A) were also evaluated. RESULTS: L. sumian showed lower antimicrobial activity when compared to L. grosso. Both lavender oils tested had no cytotoxic effect at very low concentrations, mostly L. grosso. The essential oils extracted from L. sumian and L. grosso significantly reduced NOS in a cell model. CONCLUSION: Increase in drug resistance and lack of new antibiotics may encourage the development of natural antimicrobial treatments.
Authors: Paulina Paprocka; Bonita Durnaś; Angelika Mańkowska; Karol Skłodowski; Grzegorz Król; Magdalena Zakrzewska; Michał Czarnowski; Patrycja Kot; Kamila Fortunka; Stanisław Góźdź; Paul B Savage; Robert Bucki Journal: Infect Drug Resist Date: 2021-12-25 Impact factor: 4.003