Seok Hun Jeong1,2, Yoonsuk An1,2, Choonghyun Ahn1,3,2, Boyoung Park4, Min Hyuk Lee5, Dong-Young Noh2,6, Sue K Park7,8,9,10. 1. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. 2. Cancer Research Institute, Seoul National University, Seoul, Republic of Korea. 3. Department of Biomedical Science, Seoul National University Graduate School, Seoul, Republic of Korea. 4. Department of Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea. 5. Department of Surgery, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea. 6. Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea. 7. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. suepark@snu.ac.kr. 8. Department of Biomedical Science, Seoul National University Graduate School, Seoul, Republic of Korea. suepark@snu.ac.kr. 9. Cancer Research Institute, Seoul National University, Seoul, Republic of Korea. suepark@snu.ac.kr. 10. Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine, Seoul, Republic of Korea. suepark@snu.ac.kr.
Abstract
BACKGROUND: Our main objective of this research was to analyze the effect of BMI on breast cancer risk according to various subtypes of breast cancer stratified with menopausal status. METHODS: By using a case-control study setting, we recruited a total of 16,190 female breast cancer patients aged between 35 and 80 years from 2003 to 2010. These breast cancer patients were then individually matched by age to control female group (1:2 ratios of cases and controls). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated via multivariable logistic regression by setting normal BMI range (18.5-22.9) as the reference group. RESULTS: In premenopausal women, the risk of breast cancer of triple-negative subtype increased (OR 1.60, 95% CI 1.27-2.02) in obese II (BMI ≥ 30) women and in underweight women, it was Luminal A (OR 1.24, 95% CI 1.06-1.45) and HER2 express subtype (OR 1.43, 95% CI 1.26-1.62) that showed increased risk of breast cancer. In postmenopausal women, Luminal A (OR 2.35, 95% CI 2.01-2.75), Luminal B HER2 negative (OR 1.81, 95% CI 1.46-2.25) and triple-negative subtype (OR 2.25, 95% CI 1.85-2.72) showed higher risk of breast cancer in obese II women. CONCLUSION: Our findings suggest that the effect of BMI on breast cancer differs according to various subtypes and hormone receptors and to menopausal status.
BACKGROUND: Our main objective of this research was to analyze the effect of BMI on breast cancer risk according to various subtypes of breast cancer stratified with menopausal status. METHODS: By using a case-control study setting, we recruited a total of 16,190 female breast cancerpatients aged between 35 and 80 years from 2003 to 2010. These breast cancerpatients were then individually matched by age to control female group (1:2 ratios of cases and controls). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated via multivariable logistic regression by setting normal BMI range (18.5-22.9) as the reference group. RESULTS: In premenopausal women, the risk of breast cancer of triple-negative subtype increased (OR 1.60, 95% CI 1.27-2.02) in obese II (BMI ≥ 30) women and in underweight women, it was Luminal A (OR 1.24, 95% CI 1.06-1.45) and HER2 express subtype (OR 1.43, 95% CI 1.26-1.62) that showed increased risk of breast cancer. In postmenopausal women, Luminal A (OR 2.35, 95% CI 2.01-2.75), Luminal B HER2 negative (OR 1.81, 95% CI 1.46-2.25) and triple-negative subtype (OR 2.25, 95% CI 1.85-2.72) showed higher risk of breast cancer in obese IIwomen. CONCLUSION: Our findings suggest that the effect of BMI on breast cancer differs according to various subtypes and hormone receptors and to menopausal status.
Entities:
Keywords:
Body mass index; Breast cancer; Molecular subtype; Obesity
Authors: Beata Świątkowska; Marta Szkiela; Radosław Zajdel; Dorota Kaleta Journal: Int J Environ Res Public Health Date: 2022-02-05 Impact factor: 3.390