| Literature DB >> 31626825 |
Xiyu Ke1, Gregory P Howard2, Haoyu Tang3, Bei Cheng4, May Tun Saung5, José L Santos6, Hai-Quan Mao7.
Abstract
Nanoparticles (NPs) have been gaining prominence as delivery vehicles for modulating immune responses to improve treatments against cancer and autoimmune diseases, enhancing tissue regeneration capacity, and potentiating vaccination efficacy. Various engineering approaches have been extensively explored to control the NP physical and chemical properties including particle size, shape, surface charge, hydrophobicity, rigidity and surface targeting ligands to modulate immune responses. This review examines a specific set of physical and chemical characteristics of NPs that enable efficient delivery targeted to secondary lymphoid tissues, specifically the lymph nodes and immune cells. A critical analysis of the structure-property-function relationship will facilitate further efforts to engineer new NPs with unique functionalities, identify novel utilities, and improve the clinical translation of NP formulations for immunotherapy.Entities:
Keywords: Immune cells; Immunotherapy; Lymph node; Nanoparticles; Physicochemical properties; Vaccine
Mesh：
Year: 2019 PMID： 31626825 DOI： 10.1016/j.addr.2019.09.005
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470