Fiona Schulte1,2, Alicia S Kunin-Batson3, Barbara A Olson-Bullis4, Pia Banerjee5, Matthew C Hocking6,7, Laura Janzen8, Lisa S Kahalley9, Hayley Wroot10, Caitlin Forbes11, Kevin R Krull5. 1. Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, 2202 2 St SW, Calgary, AB, T2S 3C3, Canada. Fiona.schulte@ahs.ca. 2. Alberta Children's Hospital, Calgary, Canada. Fiona.schulte@ahs.ca. 3. University of Minnesota, Minneapolis, MN, USA. 4. HealthPartners Institute, Minneapolis, MN, USA. 5. St. Jude Children's Research Hospital, Memphis, TN, USA. 6. Children's Hospital of Philadelphia, Philadelphia, PA, USA. 7. University of Pennsylvania, Philadelphia, PA, USA. 8. Hospital for Sick Children, Toronto, Ontario, Canada. 9. Baylor College of Medicine, Houston, TX, USA. 10. University of British Columbia, Vancouver, BC, Canada. 11. Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, 2202 2 St SW, Calgary, AB, T2S 3C3, Canada.
Abstract
PURPOSE: Improved therapies for pediatric central nervous system (CNS) tumors have increased survival rates; however, many survivors experience significant long-term functional limitations. Survivors of pediatric CNS tumors can experience deficits in social attainment. The aim of this review was to systematically amalgamate findings pertaining to social attainment (i.e., educational attainment, marriage, employment outcomes) in survivors of pediatric CNS tumors. METHODS: PubMed (web-based), PsycINFO (EBSCO), EMBASE (Ovid), and Web of Science (Thomson Reuters) were used to identify articles published between January 2011 and September 2018. Eligible studies reported outcomes for survivors of pediatric CNS tumors diagnosed before age 21 years and > 5 years from diagnosis and/or > 2 years off therapy. All data were independently abstracted by two reviewers. Random-effects meta-analyses were performed using Review Manager 5.0. RESULTS: The search yielded 7021 unique publications. Forty-six were included in the current review. Meta-analyses revealed survivors of CNS tumors were significantly more likely to have completed compulsory education only (OR = 1.87, 95% CI = 1.66, 2.12, p < 0.00001), less likely to be married (OR = 4.70, 95% CI = 3.89, 5.68, p < 0.00001), and more likely to be unemployed (OR = 2.84, 95% CI = 2.62, 3.08, p < 0.00001) compared to non-cancer controls. Cranial radiation therapy, neurocognitive deficits, and younger age at diagnosis were associated with poorer outcomes. Hearing loss and bilateral blindness were also related to poorer outcomes. Sex did not impact social attainment outcomes. CONCLUSIONS: Survivors of pediatric CNS tumors are at elevated risk for poor attainment of key adult social outcomes. IMPLICATIONS FOR CANCER SURVIVORS: There is a critical need to develop interventions to support survivors in becoming independent and productive adults.
PURPOSE: Improved therapies for pediatric central nervous system (CNS) tumors have increased survival rates; however, many survivors experience significant long-term functional limitations. Survivors of pediatric CNS tumors can experience deficits in social attainment. The aim of this review was to systematically amalgamate findings pertaining to social attainment (i.e., educational attainment, marriage, employment outcomes) in survivors of pediatric CNS tumors. METHODS: PubMed (web-based), PsycINFO (EBSCO), EMBASE (Ovid), and Web of Science (Thomson Reuters) were used to identify articles published between January 2011 and September 2018. Eligible studies reported outcomes for survivors of pediatric CNS tumors diagnosed before age 21 years and > 5 years from diagnosis and/or > 2 years off therapy. All data were independently abstracted by two reviewers. Random-effects meta-analyses were performed using Review Manager 5.0. RESULTS: The search yielded 7021 unique publications. Forty-six were included in the current review. Meta-analyses revealed survivors of CNS tumors were significantly more likely to have completed compulsory education only (OR = 1.87, 95% CI = 1.66, 2.12, p < 0.00001), less likely to be married (OR = 4.70, 95% CI = 3.89, 5.68, p < 0.00001), and more likely to be unemployed (OR = 2.84, 95% CI = 2.62, 3.08, p < 0.00001) compared to non-cancer controls. Cranial radiation therapy, neurocognitive deficits, and younger age at diagnosis were associated with poorer outcomes. Hearing loss and bilateral blindness were also related to poorer outcomes. Sex did not impact social attainment outcomes. CONCLUSIONS: Survivors of pediatric CNS tumors are at elevated risk for poor attainment of key adult social outcomes. IMPLICATIONS FOR CANCER SURVIVORS: There is a critical need to develop interventions to support survivors in becoming independent and productive adults.
Entities:
Keywords:
CNS tumors; Pediatric; Social attainment; Survivorship; Systematic review
Authors: Anna Font-Gonzalez; Elizabeth Lieke Feijen; Elske Sieswerda; Eline van Dulmen-den Broeder; Martha Grootenhuis; Helena Maurice-Stam; Huib Caron; Marie-Louise Essink-Bot; Helena van der Pal; Ronald Geskus; Leontien Kremer Journal: Psychooncology Date: 2015-11-23 Impact factor: 3.894
Authors: A Longaud-Valès; M Chevignard; C Dufour; J Grill; S Puget; C Sainte-Rose; D Valteau-Couanet; G Dellatolas Journal: Neuropsychol Rehabil Date: 2015-08-14 Impact factor: 2.868
Authors: Katie A Devine; William M Bukowski; Olle Jane Z Sahler; Pamela Ohman-Strickland; Tristram H Smith; E Anne Lown; Andrea Farkas Patenaude; David N Korones; Robert B Noll Journal: J Dev Behav Pediatr Date: 2016 Jul-Aug Impact factor: 2.225
Authors: Sara Ghaderi; Anders Engeland; Maria Winther Gunnes; Dag Moster; Ellen Ruud; Astri Syse; Finn Wesenberg; Tone Bjørge Journal: J Cancer Surviv Date: 2015-05-01 Impact factor: 4.442
Authors: Matthew C Hocking; Mark McCurdy; Elise Turner; Anne E Kazak; Robert B Noll; Peter Phillips; Lamia P Barakat Journal: Pediatr Blood Cancer Date: 2014-11-08 Impact factor: 3.167
Authors: Anne C Kirchhoff; Kevin R Krull; Kirsten K Ness; Elyse R Park; Kevin C Oeffinger; Melissa M Hudson; Marilyn Stovall; Leslie L Robison; Thomas Wickizer; Wendy Leisenring Journal: Cancer Date: 2011-01-18 Impact factor: 6.860
Authors: David Moher; Larissa Shamseer; Mike Clarke; Davina Ghersi; Alessandro Liberati; Mark Petticrew; Paul Shekelle; Lesley A Stewart Journal: Syst Rev Date: 2015-01-01
Authors: Clare Frobisher; Emma R Lancashire; Helen Jenkinson; David L Winter; Julie Kelly; Raoul C Reulen; Michael M Hawkins Journal: Int J Cancer Date: 2017-04-07 Impact factor: 7.396
Authors: Matthew W Parsons; Nicholas S Whipple; Matthew M Poppe; Joe S Mendez; Donald M Cannon; Lindsay M Burt Journal: J Neurooncol Date: 2020-10-31 Impact factor: 4.130
Authors: Tiina M Remes; Emma Hovén; Niina Ritari; Heli Pohjasniemi; Riina Puosi; Pekka M Arikoski; Mikko O Arola; Päivi M Lähteenmäki; Tuula R I Lönnqvist; Marja K Ojaniemi; V Pekka Riikonen; Kirsti H Sirkiä; Satu Winqvist; Heikki M J Rantala; Marika Harila; Arja H Harila-Saari Journal: Neurooncol Pract Date: 2021-01-22
Authors: Matthew C Hocking; May Albee; Cole Brodsky; Emily Shabason; Leah Wang; Robert T Schultz; John Herrington Journal: J Pediatr Psychol Date: 2021-10-18