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Literature DB >> 3162454

Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor type beta.

Abstract

Normal rat prostate epithelial cell growth requires both epidermal growth factor and heparin-binding growth factor/prostatropin. In contrast, epithelial cells derived from the transplantable Dunning R3327H rat tumor require either epidermal growth factor or heparin-binding growth factor/prostatropin. Transforming growth factor type beta inhibited normal epithelial cell growth. Transforming growth factor beta inhibited epidermal growth factor-dependent growth of tumor epithelial cells, independent of epidermal growth factor concentrations. Transforming growth factor beta increased the effective dose of heparin-binding growth factor type 1 required to support tumor epithelial cell growth by 10-fold but saturating levels of heparin-binding growth factor type 1 (290 pM) completely attenuated the inhibitory effect of transforming growth factor beta. These results suggest that prostate tumor epithelial cells may escape the inhibitory effect of transforming growth factor beta as a consequence of alteration of the concurrent requirement for both epidermal growth factor (or homologues) and heparin-binding growth factors.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 1988 PMID： 3162454 DOI： 10.1007/bf02623554

Source DB: PubMed Journal: In Vitro Cell Dev Biol ISSN： 0883-8364

13 in total

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Authors: G D Shipley; M R Pittelkow; J J Wille; R E Scott; H L Moses
Journal: Cancer Res Date: 1986-04 Impact factor: 12.701

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Authors: J B McMahon; W L Richards; A A del Campo; M K Song; S S Thorgeirsson
Journal: Cancer Res Date: 1986-09 Impact factor: 12.701

3. Isolation and characterization of different molecular and chromatographic forms of heparin-binding growth factor 1 from bovine brain.

Authors: W L McKeehan; J W Crabb
Journal: Anal Biochem Date: 1987-08-01 Impact factor: 3.365

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Authors: I Hayashi; B I Carr
Journal: J Cell Physiol Date: 1985-10 Impact factor: 6.384

5. Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture.

Authors: W L McKeehan; P S Adams; M P Rosser
Journal: Cancer Res Date: 1984-05 Impact factor: 12.701

6. Complete primary structure of prostatropin, a prostate epithelial cell growth factor.

Authors: J W Crabb; L G Armes; S A Carr; C M Johnson; G D Roberts; R S Bordoli; W L McKeehan
Journal: Biochemistry Date: 1986-09-09 Impact factor: 3.162

7. Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial epithelial cells.

Authors: J F Lechner; I A McClendon; M A LaVeck; A M Shamsuddin; C C Harris
Journal: Cancer Res Date: 1983-12 Impact factor: 12.701

8. Different hormonal requirements for androgen-independent growth of normal and tumor epithelial cells from rat prostate.

Authors: W L McKeehan; P S Adams; D Fast
Journal: In Vitro Cell Dev Biol Date: 1987-02

9. TGF-beta inhibition of endothelial cell proliferation: alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression.

Authors: K Takehara; E C LeRoy; G R Grotendorst
Journal: Cell Date: 1987-05-08 Impact factor: 41.582

10. Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

Authors: T Masui; L M Wakefield; J F Lechner; M A LaVeck; M B Sporn; C C Harris
Journal: Proc Natl Acad Sci U S A Date: 1986-04 Impact factor: 11.205

12 in total

Review 1. Active cell death in hormone-dependent tissues.

Authors: M P Tenniswood; R S Guenette; J Lakins; M Mooibroek; P Wong; J E Welsh
Journal: Cancer Metastasis Rev Date: 1992-09 Impact factor: 9.264

Review 2. Growth factors as mediators of androgen action during the development of the male urogenital tract.

Authors: G R Cunha; B Foster; A Thomson; Y Sugimura; N Tanji; M Tsuji; N Terada; P W Finch; A A Donjacour
Journal: World J Urol Date: 1995 Impact factor: 4.226

3. Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

Authors: M Kan; J S Huang; P E Mansson; H Yasumitsu; B Carr; W L McKeehan
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

4. Serum-free culture of enriched mouse anterior and ventral prostatic epithelial cells in collagen gel.

Authors: T Turner; H A Bern; P Young; G R Cunha
Journal: In Vitro Cell Dev Biol Date: 1990-07

5. Heparin-binding (fibroblast) growth factors are potential autocrine regulators of esophageal epithelial cell proliferation.

Authors: M Katayama; M Kan
Journal: In Vitro Cell Dev Biol Date: 1991-07

Review 6. Transforming growth factor-beta and prostate cancer.

Authors: M S Steiner
Journal: World J Urol Date: 1995 Impact factor: 4.226

7. Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

Authors: G Yan; Y Fukabori; G McBride; S Nikolaropolous; W L McKeehan
Journal: Mol Cell Biol Date: 1993-08 Impact factor: 4.272

Review 8. Spinal cord compression in prostate cancer.

Authors: J L Osborn; R H Getzenberg; D L Trump
Journal: J Neurooncol Date: 1995 Impact factor: 4.130

Review 9. Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer.

Authors: J L Ware
Journal: Cancer Metastasis Rev Date: 1993-09 Impact factor: 9.264

10. Establishment and characterization of an immortalized but non-transformed human prostate epithelial cell line: BPH-1.

Authors: S W Hayward; R Dahiya; G R Cunha; J Bartek; N Deshpande; P Narayan
Journal: In Vitro Cell Dev Biol Anim Date: 1995-01 Impact factor: 2.416