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Literature DB >> 31617599

Role reversal: adaptive immunity instructs inflammasome activation for anti-viral defence.

Abstract

Signalling by innate immune cells is critical to shaping the adaptive immune response to microbial infection. In this issue of The EMBO Journal, Labzin et al reveal that the adaptive immune system can instruct the innate response to adenovirus infection. In human macrophages, antibody-coated adenovirus triggers a novel TRIM21-dependent pathway that activates the NLRP3 inflammasome and the secretion of IL-1β.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2019 PMID： 31617599 PMCID： PMC6826213 DOI： 10.15252/embj.2019103533

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

13 in total

Review 1. The interleukin-1 family: back to the future.

Authors: Cecilia Garlanda; Charles A Dinarello; Alberto Mantovani
Journal: Immunity Date: 2013-12-12 Impact factor: 31.745

2. Role reversal: adaptive immunity instructs inflammasome activation for anti-viral defence.

Authors: Rebecca C Coll
Journal: EMBO J Date: 2019-10-16 Impact factor: 11.598

3. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.

Authors: Sebastian Rühl; Kateryna Shkarina; Benjamin Demarco; Rosalie Heilig; José Carlos Santos; Petr Broz
Journal: Science Date: 2018-11-23 Impact factor: 47.728

4. Adenovirus membrane penetration activates the NLRP3 inflammasome.

Authors: A U Barlan; T M Griffin; K A McGuire; C M Wiethoff
Journal: J Virol Date: 2010-10-27 Impact factor: 5.103

Review 5. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).

Authors: K L Winthrop; X Mariette; J T Silva; E Benamu; L H Calabrese; A Dumusc; J S Smolen; J M Aguado; M Fernández-Ruiz
Journal: Clin Microbiol Infect Date: 2018-02-12 Impact factor: 8.067

Review 6. How Inflammasomes Inform Adaptive Immunity.

Authors: Charles L Evavold; Jonathan C Kagan
Journal: J Mol Biol Date: 2017-10-05 Impact factor: 5.469

Review 7. The NLRP3 inflammasome: molecular activation and regulation to therapeutics.

Authors: Karen V Swanson; Meng Deng; Jenny P-Y Ting
Journal: Nat Rev Immunol Date: 2019-08 Impact factor: 53.106

8. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

Authors: Moritz M Gaidt; Thomas S Ebert; Dhruv Chauhan; Katharina Ramshorn; Francesca Pinci; Sarah Zuber; Fionan O'Duill; Jonathan L Schmid-Burgk; Florian Hoss; Raymund Buhmann; Georg Wittmann; Eicke Latz; Marion Subklewe; Veit Hornung
Journal: Cell Date: 2017-10-12 Impact factor: 41.582

Role reversal: adaptive immunity instructs inflammasome activation for anti-viral defence.

Review 1. The interleukin-1 family: back to the future.

2. Role reversal: adaptive immunity instructs inflammasome activation for anti-viral defence.

3. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation.

4. Adenovirus membrane penetration activates the NLRP3 inflammasome.

Review 5. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [II]: agents targeting interleukins, immunoglobulins and complement factors).

Review 6. How Inflammasomes Inform Adaptive Immunity.

Review 7. The NLRP3 inflammasome: molecular activation and regulation to therapeutics.

8. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.

9. Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection.

Review 10. TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity.

1. Role reversal: adaptive immunity instructs inflammasome activation for anti-viral defence.

Review 2. TRIM Proteins in Inflammation: from Expression to Emerging Regulatory Mechanisms.