Literature DB >> 31617510

Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT).

Ikuhiko Nakase1, Miku Katayama, Yoshihide Hattori, Miki Ishimura, Shunsuke Inaura, Daisuke Fujiwara, Tomoka Takatani-Nakase, Ikuo Fujii, Shiroh Futaki, Mitsunori Kirihata.   

Abstract

In this study, we designed and synthesized organelle-targeted cell-penetrating peptide (CPP)-conjugated boron compounds to increase their cellular uptake and to control the intracellular locations for the induction of sophisticated anticancer biological activity in boron neutron capture therapy (BNCT), leading to anticancer effects with ATP reduction and apoptosis when irradiated with neutrons in an in vitro BNCT assay.

Entities:  

Year:  2019        PMID： 31617510     DOI： 10.1039/c9cc03924d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy.

Authors:  Yoshihide Hattori; Miki Ishimura; Youichirou Ohta; Hiroshi Takenaka; Shinji Kawabata; Mitsunori Kirihata
Journal:  ACS Med Chem Lett       Date:  2021-12-01       Impact factor: 4.345

2.  Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems.

Authors:  Hironobu Yanagie; Masashi Yanagawa; Yasuyuki Morishita; Atsuko Shinohara; Novriana Dewi; Yasumasa Nonaka; Yoshitaka Furuya; Ryouji Mizumachi; Yuuji Murata; Hiroyuki Nakamura; Minoru Suzuki; Yoshinori Sakurai; Hiroki Tanaka; Shinichiro Masunaga; Koji Ono; Takumichi Sugihara; Masayuki Nashimoto; Haruo Yamauchi; Minoru Ono; Jun Nakajima; Hiroyuki Takahashi
Journal:  In Vivo       Date:  2021 Nov-Dec       Impact factor: 2.155

Review 3.  Theranostics in Boron Neutron Capture Therapy.

Authors:  Wolfgang A G Sauerwein; Lucie Sancey; Evamarie Hey-Hawkins; Martin Kellert; Luigi Panza; Daniela Imperio; Marcin Balcerzyk; Giovanna Rizzo; Elisa Scalco; Ken Herrmann; PierLuigi Mauri; Antonella De Palma; Andrea Wittig
Journal:  Life (Basel)       Date:  2021-04-10

Review 4.  Carboranes as unique pharmacophores in antitumor medicinal chemistry.

Authors:  Yu Chen; Fukuan Du; Liyao Tang; Jinrun Xu; Yueshui Zhao; Xu Wu; Mingxing Li; Jing Shen; Qinglian Wen; Chi Hin Cho; Zhangang Xiao
Journal:  Mol Ther Oncolytics       Date:  2022-01-10       Impact factor: 7.200

Review 5.  Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment.

Authors:  Dominika Skwierawska; José Antonio López-Valverde; Marcin Balcerzyk; Antonio Leal
Journal:  Cancers (Basel)       Date:  2022-06-10       Impact factor: 6.575

Review 6.  Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies.

Authors:  Paul Hoppenz; Sylvia Els-Heindl; Annette G Beck-Sickinger
Journal:  Front Chem       Date:  2020-07-07       Impact factor: 5.221

7.  Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications.

Authors:  Ghadir Kalot; Amélie Godard; Benoît Busser; Jacques Pliquett; Mans Broekgaarden; Vincent Motto-Ros; Karl David Wegner; Ute Resch-Genger; Ulli Köster; Franck Denat; Jean-Luc Coll; Ewen Bodio; Christine Goze; Lucie Sancey
Journal:  Cells       Date:  2020-08-25       Impact factor: 6.600
  7 in total

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