Literature DB >> 35059123

Dodecaborate Conjugates Targeting Tumor Cell Overexpressing Translocator Protein for Boron Neutron Capture Therapy.

Yoshihide Hattori1, Miki Ishimura1,2, Youichirou Ohta1,2, Hiroshi Takenaka1,2, Shinji Kawabata3, Mitsunori Kirihata1.   

Abstract

We developed novel closo-dodecaborate ([B12H11]2-) anion-containing translocator protein (TSPO) ligand as a boron carrier for boron neutron capture therapy. This compound shows high water solubility and can deliver boron to TSPO highly expressed in breast cancer cells. We describe the synthesis and in vitro evaluation of a dodecaborate-based pyrazolopyrimidine.
© 2021 American Chemical Society.

Entities:  

Year:  2021        PMID： 35059123      PMCID： PMC8762747          DOI： 10.1021/acsmedchemlett.1c00377

Source DB:  PubMed          Journal:  ACS Med Chem Lett        ISSN： 1948-5875            Impact factor:   4.345


  33 in total

1.  The Chemistry of Neutron Capture Therapy.

Authors:  Albert H. Soloway; Werner Tjarks; Beverly A. Barnum; Feng-Guang Rong; Rolf F. Barth; Iwona M. Codogni; J. Gerald Wilson
Journal:  Chem Rev       Date:  1998-06-18       Impact factor: 60.622

2.  Synthesis of optically active dodecaborate-containing L-amino acids for BNCT.

Authors:  Shintaro Kusaka; Yoshihide Hattori; Kouki Uehara; Tomoyuki Asano; Shinji Tanimori; Mitsunori Kirihata
Journal:  Appl Radiat Isot       Date:  2011-04-08       Impact factor: 1.513

3.  Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT).

Authors:  Ikuhiko Nakase; Miku Katayama; Yoshihide Hattori; Miki Ishimura; Shunsuke Inaura; Daisuke Fujiwara; Tomoka Takatani-Nakase; Ikuo Fujii; Shiroh Futaki; Mitsunori Kirihata
Journal:  Chem Commun (Camb)       Date:  2019-11-19       Impact factor: 6.222

4.  Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies.

Authors:  G Le Fur; N Vaucher; M L Perrier; A Flamier; J Benavides; C Renault; M C Dubroeucq; C Guérémy; A Uzan
Journal:  Life Sci       Date:  1983-08-01       Impact factor: 5.037

Review 5.  Boron neutron capture therapy of cancer: current status and future prospects.

Authors:  Rolf F Barth; Jeffrey A Coderre; M Graça H Vicente; Thomas E Blue
Journal:  Clin Cancer Res       Date:  2005-06-01       Impact factor: 12.531

6.  Translocator protein blockade reduces prostate tumor growth.

Authors:  Arlee Fafalios; Ardavan Akhavan; Anil V Parwani; Robert R Bies; Kevin J McHugh; Beth R Pflug
Journal:  Clin Cancer Res       Date:  2009-09-29       Impact factor: 12.531

7.  Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106.

Authors:  Fumihiko Yasuno; Miho Ota; Jun Kosaka; Hiroshi Ito; Makoto Higuchi; Talant K Doronbekov; Shoko Nozaki; Yota Fujimura; Michihiko Koeda; Takashi Asada; Tetsuya Suhara
Journal:  Biol Psychiatry       Date:  2008-06-02       Impact factor: 13.382

8.  TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells.

Authors:  Mariarosa Rechichi; Alessandra Salvetti; Beatrice Chelli; Barbara Costa; Eleonora Da Pozzo; Francesca Spinetti; Annalisa Lena; Monica Evangelista; Giuseppe Rainaldi; Claudia Martini; Vittorio Gremigni; Leonardo Rossi
Journal:  Biochim Biophys Acta       Date:  2007-12-15

9.  Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival.

Authors:  Sylvaine Galiègue; Pierre Casellas; Andrew Kramar; Norbert Tinel; Joelle Simony-Lafontaine
Journal:  Clin Cancer Res       Date:  2004-03-15       Impact factor: 12.531

10.  Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides.

Authors:  Rajeshwar Narlawar; Christopher J D Austin; Jan Kahlert; Silvia Selleri; Eleonora Da Pozzo; Claudia Martini; Eryn L Werry; Louis M Rendina; Michael Kassiou
Journal:  Chem Asian J       Date:  2018-10-17
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