Literature DB >> 3161487

The value of tocainide in the treatment of tinnitus. A double-blind controlled study.

J H Hulshof, P Vermeij.   

Abstract

We assessed the value of tocainide in the treatment of tinnitus by performing a double-blind controlled trial in which each of 48 patients with annoying tinnitus received either tocainide HC1 900 mg/day or a placebo. Before the trial, the effect of intravenous lidocaine was evaluated in each patient so that both lidocaine and tocainide could be compared in altering tinnitus. We found that tocainide appeared to have no better effect than the placebo, whereas lidocaine suppressed tinnitus in 81% of the patients treated. The mechanisms of action of both drugs as well as their influence on tinnitus are discussed, as are the side effects of tocainide.

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Year:  1985        PMID： 3161487     DOI： 10.1007/bf00453701

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  8 in total

1.  Local anaesthetics and tinnitus. Proposed peripheral mechanism of action of lidocaine.

Authors:  L Lyttkens; B Larsson; S A Wästerström
Journal:  ORL J Otorhinolaryngol Relat Spec       Date:  1984       Impact factor: 1.538

2.  Pharmacological properties of sodium channels in nerve membranes.

Authors:  G R Strichartz
Journal:  Adv Neurol       Date:  1981

3.  Assessment of the value of tocainide hydrochloride in the treatment of tinnitus.

Authors:  J M Cathcart
Journal:  J Laryngol Otol       Date:  1982-11       Impact factor: 1.469

4.  Tinnitus: a double-blind crossover controlled trial to evaluate the use of lignocaine.

Authors:  F W Martin; B H Colman
Journal:  Clin Otolaryngol Allied Sci       Date:  1980-02

5.  Lidocaine in the treatment of tinnitus aurium. A double-blind study.

Authors:  J M Israel; J S Connelly; S T McTigue; R E Brummett; J Brown
Journal:  Arch Otolaryngol       Date:  1982-08

6.  The effect of intra-venous lidocaine and several different doses oral tocainide HCl on tinnitus. A dose-finding study.

Authors:  J H Hulshof; P Vermeij
Journal:  Acta Otolaryngol       Date:  1984 Sep-Oct       Impact factor: 1.494

7.  Treatment of tinnitus with tocainide hydrochloride.

Authors:  J R Emmett; J J Shea
Journal:  Otolaryngol Head Neck Surg       Date:  1980 Jul-Aug       Impact factor: 3.497

8.  Attemps to relieve tinnitus.

Authors:  J Vernon
Journal:  J Am Audiol Soc       Date:  1977 Jan-Feb
  8 in total
  6 in total

Review 1.  Drugs affecting the inner ear. A review of their clinical efficacy, mechanisms of action, toxicity, and place in therapy.

Authors:  C H Norris
Journal:  Drugs       Date:  1988-12       Impact factor: 9.546

2.  PHARMACOLOGICAL TREATMENTS FOR TINNITUS: NEW AND OLD.

Authors:  R Salvi; E Lobarinas; W Sun
Journal:  Drugs Future       Date:  2009       Impact factor: 0.148

Review 3.  A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.

Authors:  Hans-Peter Zenner; Wolfgang Delb; Birgit Kröner-Herwig; Burkhard Jäger; Ingrid Peroz; Gerhard Hesse; Birgit Mazurek; Gerhard Goebel; Christian Gerloff; Regina Trollmann; Eberhard Biesinger; Harald Seidler; Berthold Langguth
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-12-19       Impact factor: 2.503

Review 4.  Emerging pharmacotherapy of tinnitus.

Authors:  Berthold Langguth; Richard Salvi; Ana Belén Elgoyhen
Journal:  Expert Opin Emerg Drugs       Date:  2009-12       Impact factor: 4.191

5.  Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series.

Authors:  Gentiana Ioana Wenzel; Athanasia Warnecke; Timo Stöver; Thomas Lenarz
Journal:  Eur Arch Otorhinolaryngol       Date:  2009-10-22       Impact factor: 2.503

6.  Tinnitus: network pathophysiology-network pharmacology.

Authors:  Ana B Elgoyhen; Berthold Langguth; Sven Vanneste; Dirk De Ridder
Journal:  Front Syst Neurosci       Date:  2012-01-25
  6 in total

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