Literature DB >> 31608650

Modeling Ketogenesis for Use in Pediatric Diabetes Simulation.

Catherina Pinnaro1, Gary E Christensen2,3, Vanessa Curtis1.   

Abstract

BACKGROUND: Simulation is being increasingly integrated into medical education. Diabetes simulation is well-received by trainees and has demonstrated improved clinical results, including reduced adult inpatient hyperglycemia. However, no pediatric-specific diabetes simulation programs exist for use in medical education. None of the existing diabetes models incorporate ketones as an input or an output, which is essential for use in teaching pediatric diabetes management.
METHODS: We created a pediatric diabetes simulation incorporating both blood sugar and urine ketones as output. Ketone output is implemented as a state variable but is obfuscated to simulate hospital experience. Blood sugar output is similar to other models and incorporates the current blood sugar, insulin on board (IOB) and carbohydrates on board (COB), and insulin and carbohydrate sensitivities. The program calculates all IOB and COB every 15 minutes based on user input and provides written summary feedback at the end of the simulation about inaccurate dosing and timing.
RESULTS: The simulation realistically incorporated both blood glucose and urine ketones in clinically valid and actionable formats. After completing this simulation, 16/17 pediatric residents indicated that they wanted more simulated diabetes cases integrated into their curriculum.
CONCLUSION: Implementing simulation into pediatric diabetes education was feasible and well-received. More work is needed to further study the role of simulation in pediatric diabetes education when used adjunctively or in lieu of lectures when time or resources are limited.

Entities:  

Keywords:  ketones; pediatrics; simulation; type 1 diabetes

Year:  2019        PMID: 31608650      PMCID: PMC8256079          DOI: 10.1177/1932296819882058

Source DB:  PubMed          Journal:  J Diabetes Sci Technol        ISSN: 1932-2968


  31 in total

1.  Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo.

Authors:  L Heinemann; R Linkeschova; K Rave; B Hompesch; M Sedlak; T Heise
Journal:  Diabetes Care       Date:  2000-05       Impact factor: 19.112

2.  Trends in the prevalence of ketoacidosis at diabetes diagnosis: the SEARCH for diabetes in youth study.

Authors:  Dana Dabelea; Arleta Rewers; Jeanette M Stafford; Debra A Standiford; Jean M Lawrence; Sharon Saydah; Giuseppina Imperatore; Ralph B D'Agostino; Elizabeth J Mayer-Davis; Catherine Pihoker
Journal:  Pediatrics       Date:  2014-03-31       Impact factor: 7.124

3.  Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002-2012.

Authors:  Elizabeth J Mayer-Davis; Jean M Lawrence; Dana Dabelea; Jasmin Divers; Scott Isom; Lawrence Dolan; Giuseppina Imperatore; Barbara Linder; Santica Marcovina; David J Pettitt; Catherine Pihoker; Sharon Saydah; Lynne Wagenknecht
Journal:  N Engl J Med       Date:  2017-04-13       Impact factor: 91.245

Review 4.  Blood Ketones: Measurement, Interpretation, Limitations, and Utility in the Management of Diabetic Ketoacidosis.

Authors:  Ketan Dhatariya
Journal:  Rev Diabet Stud       Date:  2017-02-10

5.  Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion.

Authors:  Caroline Bonner; Julie Kerr-Conte; Valéry Gmyr; Gurvan Queniat; Ericka Moerman; Julien Thévenet; Cédric Beaucamps; Nathalie Delalleau; Iuliana Popescu; Willy J Malaisse; Abdullah Sener; Benoit Deprez; Amar Abderrahmani; Bart Staels; François Pattou
Journal:  Nat Med       Date:  2015-04-20       Impact factor: 53.440

6.  Diabetes: Models, Signals, and Control.

Authors:  Claudio Cobelli; Chiara Dalla Man; Giovanni Sparacino; Lalo Magni; Giuseppe De Nicolao; Boris P Kovatchev
Journal:  IEEE Rev Biomed Eng       Date:  2009-01-01

7.  Geographic distribution of childhood diabetes and obesity relative to the supply of pediatric endocrinologists in the United States.

Authors:  Joyce M Lee; Matthew M Davis; Ram K Menon; Gary L Freed
Journal:  J Pediatr       Date:  2007-11-05       Impact factor: 4.406

8.  Model predictive control of type 1 diabetes: an in silico trial.

Authors:  Lalo Magni; Davide M Raimondo; Luca Bossi; Chiara Dalla Man; Giuseppe De Nicolao; Boris Kovatchev; Claudio Cobelli
Journal:  J Diabetes Sci Technol       Date:  2007-11

9.  The UVA/PADOVA Type 1 Diabetes Simulator: New Features.

Authors:  Chiara Dalla Man; Francesco Micheletto; Dayu Lv; Marc Breton; Boris Kovatchev; Claudio Cobelli
Journal:  J Diabetes Sci Technol       Date:  2014-01-01

10.  Severe hypoglycemia and diabetic ketoacidosis among youth with type 1 diabetes in the T1D Exchange clinic registry.

Authors:  Eda Cengiz; Dongyuan Xing; Jenise C Wong; Joseph I Wolfsdorf; Morey W Haymond; Arleta Rewers; Satya Shanmugham; William V Tamborlane; Steven M Willi; Diane L Seiple; Kellee M Miller; Stephanie N DuBose; Roy W Beck
Journal:  Pediatr Diabetes       Date:  2013-03-08       Impact factor: 4.866

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