Erin D Bigler1,2, Tracy J Abildskov1,2, Barry Eggleston3, Brian A Taylor4, David F Tate5, Jo Ann Petrie1,2, Mary R Newsome6, Randall S Scheibel6, Harvey Levin6, William C Walker4, Naomi Goodrich-Hunsaker2,7, Nicholas J Tustison7, James R Stone7, Andrew R Mayer8, Timothy D Duncan9, Gerry E York10, Elisabeth A Wilde6,2. 1. Psychology Department and Neuroscience Center, Brigham Young University, Provo, Utah. 2. Department of Neurology, University of Utah, Salt Lake City, Utah. 3. Biostatistics and Epidemiology, RTI International, Durham, North Carolina. 4. Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia. 5. Missouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, Missouri. 6. Michael DeBakey VA Medical Center and Baylor College of Medicine, Houston, Texas. 7. Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia. 8. Neurology and Brain and Behavioral Health Institute, University of New Mexico, Albuquerque, New Mexico. 9. Medical Imaging and Radiology, VA Portland Health Care System, Portland, Oregon. 10. Alaska Radiology Associates, TBI Imaging and Research, Anchorage, Alaska.
Abstract
OBJECTIVES: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies-Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. METHODS: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. RESULTS: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. CONCLUSIONS/DISCUSSION: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.
OBJECTIVES: The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long-term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow-on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies-Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. METHODS: The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. RESULTS: At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. CONCLUSIONS/DISCUSSION: The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.
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