Li Fan1, Weihao Xu1, Yulun Cai1, Yixin Hu2, Chenkai Wu3. 1. Geriatric Cardiology Department of The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China. 2. Geriatric Health Care Department of The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China. Electronic address: 421297919@qq.com. 3. Global Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China; Duke Global Health Institute, Duke University, Durham, NC. Electronic address: chenkai.wu@dukekunshan.edu.cn.
Abstract
OBJECTIVE: Epidemiologic studies have reported inconsistent findings about the association between sleep duration and the risk of dementia. We aimed to clarify this association by method of meta-analysis. DESIGN: Systematic review and meta-analysis of prospective cohort studies. SETTING AND PARTICIPANTS: Community or clinical settings. Participants included patients with dementia or Alzheimer's disease and the general population. MEASURES: We systematically searched the PubMed, EMBASE, and Web of Science for prospective cohort studies investigating the association between sleep duration and all-cause dementia or Alzheimer's disease (AD). Generic inverse-variance method was used to combine the outcomes with a random effects model for the association between sleep duration (short or long vs normal) and all-cause dementia or AD. RESULTS: We identified 7 studies for all-cause dementia and 6 studies for AD. Pooled analyses showed that long sleep duration was associated with a 77% increased risk of all-cause dementia [hazard ratio (HR) = 1.77, 95% confidence interval (CI) = 1.32-2.37] and a 63% increased risk of AD (HR = 1.63, 95% CI = 1.24-2.13). Short sleep duration was not statistically associated with an increased risk of all-cause dementia (HR = 1.20, 95% CI = 0.91-1.59) or AD (HR = 1.18, 95% CI = 0.91-1.54). CONCLUSIONS AND IMPLICATIONS: Only long sleep duration is significantly associated with an increased risk of all-dementia and AD. Future studies are needed to better understand the mechanisms underlying this association.
OBJECTIVE: Epidemiologic studies have reported inconsistent findings about the association between sleep duration and the risk of dementia. We aimed to clarify this association by method of meta-analysis. DESIGN: Systematic review and meta-analysis of prospective cohort studies. SETTING AND PARTICIPANTS: Community or clinical settings. Participants included patients with dementia or Alzheimer's disease and the general population. MEASURES: We systematically searched the PubMed, EMBASE, and Web of Science for prospective cohort studies investigating the association between sleep duration and all-cause dementia or Alzheimer's disease (AD). Generic inverse-variance method was used to combine the outcomes with a random effects model for the association between sleep duration (short or long vs normal) and all-cause dementia or AD. RESULTS: We identified 7 studies for all-cause dementia and 6 studies for AD. Pooled analyses showed that long sleep duration was associated with a 77% increased risk of all-cause dementia [hazard ratio (HR) = 1.77, 95% confidence interval (CI) = 1.32-2.37] and a 63% increased risk of AD (HR = 1.63, 95% CI = 1.24-2.13). Short sleep duration was not statistically associated with an increased risk of all-cause dementia (HR = 1.20, 95% CI = 0.91-1.59) or AD (HR = 1.18, 95% CI = 0.91-1.54). CONCLUSIONS AND IMPLICATIONS: Only long sleep duration is significantly associated with an increased risk of all-dementia and AD. Future studies are needed to better understand the mechanisms underlying this association.
Authors: Caitlan A Tighe; Daniel J Buysse; Debra K Weiner; Gregory P Beehler; Daniel E Forman Journal: J Cardiopulm Rehabil Prev Date: 2022-05-02 Impact factor: 3.646
Authors: Anders M Fjell; Øystein Sørensen; Inge K Amlien; David Bartrés-Faz; Andreas M Brandmaier; Nikolaus Buchmann; Ilja Demuth; Christian A Drevon; Sandra Düzel; Klaus P Ebmeier; Paolo Ghisletta; Ane-Victoria Idland; Tim C Kietzmann; Rogier A Kievit; Simone Kühn; Ulman Lindenberger; Fredrik Magnussen; Didac Macià; Athanasia M Mowinckel; Lars Nyberg; Claire E Sexton; Cristina Solé-Padullés; Sara Pudas; James M Roe; Donatas Sederevicius; Sana Suri; Didac Vidal-Piñeiro; Gerd Wagner; Leiv Otto Watne; René Westerhausen; Enikő Zsoldos; Kristine B Walhovd Journal: Cereb Cortex Date: 2021-03-05 Impact factor: 5.357