Literature DB >> 32951248

Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders.

Yue Leng1, Sarah F Ackley2, Maria M Glymour2, Kristine Yaffe1,2,3,4, Willa D Brenowitz1.   

Abstract

Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD predicts sleep duration using a genetic risk score (GRS) for AD (AD-GRS), in 406,536 UK Biobank participants with European ancestry and without dementia at enrollment. Higher AD-GRS score was associated with shorter sleep (b = -0.014, 95% confidence interval [CI] = -0.022 to -0.006), especially in those aged 55+. Using AD-GRS as an instrumental variable for AD diagnosis, incipient AD reduced sleep duration by 1.87 hours (95% CI = 0.96, 2.78). Short sleep duration might be an early marker of AD. ANN NEUROL 2021;89:177-181.
© 2020 American Neurological Association.

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Year:  2020        PMID： 32951248      PMCID： PMC8048405          DOI： 10.1002/ana.25910

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  19 in total

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Review 4.  Sleep in normal aging and dementia.

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6.  UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age.

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6.  Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife.

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