| Literature DB >> 31604276 |
Jennifer R Gruhn1, Agata P Zielinska2, Vallari Shukla1, Robert Blanshard3,4, Antonio Capalbo5, Danilo Cimadomo6, Dmitry Nikiforov7,8, Andrew Chi-Ho Chan1, Louise J Newnham3, Ivan Vogel1, Catello Scarica9, Marta Krapchev10, Deborah Taylor11, Stine Gry Kristensen7, Junping Cheng7, Erik Ernst12, Anne-Mette Bay Bjørn12, Lotte Berdiin Colmorn13, Martyn Blayney14, Kay Elder14, Joanna Liss10,15, Geraldine Hartshorne11, Marie Louise Grøndahl16, Laura Rienzi6, Filippo Ubaldi6, Rajiv McCoy17, Krzysztof Lukaszuk10,18,19, Claus Yding Andersen7, Melina Schuh2, Eva R Hoffmann20.
Abstract
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.Entities:
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Year: 2019 PMID： 31604276 PMCID： PMC7212007 DOI： 10.1126/science.aav7321
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728