Literature DB >> 31594437

Delayed recanalization in acute ischemic stroke patients: Late is better than never?

Jinwei Pang1, John H Zhang2, Yong Jiang1.   

Abstract

Successful recanalization of the occluded vessel as early as possible has been widely accepted as the key principle of acute ischemic stroke (AIS) treatment. Unfortunately, for many years, the vast majority of AIS patients were prevented from receiving effective recanalization therapy because of a narrow therapeutic window. Recently, a series of inspiring clinical trials have indicated that more patients may benefit from delayed recanalization during an expanded therapeutic window, even up to 24 h after symptom onset. However, could potentially salvageable brain tissue (penumbra) in patients who do not receive medication within 24 h still possible to be saved?

Entities:  

Keywords:  Acute ischemic stroke; clinical trials; delayed recanalization; penumbra; therapeutic window

Mesh：

Year:  2019        PMID： 31594437      PMCID： PMC6893989          DOI： 10.1177/0271678X19881449

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  10 in total

1.  CT perfusion guided delayed recanalization with favorable outcome in pediatric stroke.

Authors:  Andrew Xavier; Amit Kansara; Aniel Q Majjhoo; Gregory Norris
Journal:  J Neurointerv Surg       Date:  2011-12-05       Impact factor: 5.836

2.  Safety and efficacy of thrombectomy in acute ischaemic stroke (REVASCAT): 1-year follow-up of a randomised open-label trial.

Authors:  Antoni Dávalos; Erik Cobo; Carlos A Molina; Angel Chamorro; M Angeles de Miquel; Luis San Román; Joaquín Serena; Elena López-Cancio; Marc Ribó; Mónica Millán; Xabier Urra; Pere Cardona; Alejandro Tomasello; Carlos Castaño; Jordi Blasco; Lucía Aja; Marta Rubiera; Meritxell Gomis; Arturo Renú; Blanca Lara; Joan Martí-Fàbregas; Brian Jankowitz; Neus Cerdà; Tudor G Jovin
Journal:  Lancet Neurol       Date:  2017-03-16       Impact factor: 44.182

3.  Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats.

Authors:  Wen Zheng; Nathanael Matei; Jinwei Pang; Xu Luo; Zhi Song; Jiping Tang; John H Zhang
Journal:  Exp Neurol       Date:  2019-07-08       Impact factor: 5.330

4.  Extending thrombolysis to 4·5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data.

Authors:  Bruce C V Campbell; Henry Ma; Peter A Ringleb; Mark W Parsons; Leonid Churilov; Martin Bendszus; Christopher R Levi; Chung Hsu; Timothy J Kleinig; Marc Fatar; Didier Leys; Carlos Molina; Tissa Wijeratne; Sami Curtze; Helen M Dewey; P Alan Barber; Kenneth S Butcher; Deidre A De Silva; Christopher F Bladin; Nawaf Yassi; Johannes A R Pfaff; Gagan Sharma; Andrew Bivard; Patricia M Desmond; Stefan Schwab; Peter D Schellinger; Bernard Yan; Peter J Mitchell; Joaquín Serena; Danilo Toni; Vincent Thijs; Werner Hacke; Stephen M Davis; Geoffrey A Donnan
Journal:  Lancet       Date:  2019-05-22       Impact factor: 79.321

5.  DAWN and DEFUSE-3 trials: is time still important?

Authors:  A Ragoschke-Schumm; S Walter
Journal:  Radiologe       Date:  2018-11       Impact factor: 0.635

6.  Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion.

Authors:  Devin William McBride; Guangyong Wu; Derek Nowrangi; Jerry J Flores; Liang Hui; Paul R Krafft; John H Zhang
Journal:  Transl Stroke Res       Date:  2018-01-21       Impact factor: 6.829

7.  Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke.

Authors:  Henry Ma; Bruce C V Campbell; Mark W Parsons; Leonid Churilov; Christopher R Levi; Chung Hsu; Timothy J Kleinig; Tissa Wijeratne; Sami Curtze; Helen M Dewey; Ferdinand Miteff; Chon-Haw Tsai; Jiunn-Tay Lee; Thanh G Phan; Neil Mahant; Mu-Chien Sun; Martin Krause; Jonathan Sturm; Rohan Grimley; Chih-Hung Chen; Chaur-Jong Hu; Andrew A Wong; Deborah Field; Yu Sun; P Alan Barber; Arman Sabet; Jim Jannes; Jiann-Shing Jeng; Benjamin Clissold; Romesh Markus; Ching-Huang Lin; Li-Ming Lien; Christopher F Bladin; Søren Christensen; Nawaf Yassi; Gagan Sharma; Andrew Bivard; Patricia M Desmond; Bernard Yan; Peter J Mitchell; Vincent Thijs; Leeanne Carey; Atte Meretoja; Stephen M Davis; Geoffrey A Donnan
Journal:  N Engl J Med       Date:  2019-05-09       Impact factor: 91.245

8.  Persistent Target Mismatch Profile >24 Hours After Stroke Onset in DEFUSE 3.

Authors:  Søren Christensen; Michael Mlynash; Stephanie Kemp; Amarnath Yennu; Jeremy J Heit; Michael P Marks; Maarten G Lansberg; Gregory W Albers
Journal:  Stroke       Date:  2019-03       Impact factor: 10.170

9.  Two-year clinical follow-up of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN): design and statistical analysis plan of the extended follow-up study.

Authors:  Lucie A van den Berg; Marcel G W Dijkgraaf; Olvert A Berkhemer; Puck S S Fransen; Debbie Beumer; Hester Lingsma; Charles B M Majoie; Diederik W J Dippel; Aad J van der Lugt; Robert J van Oostenbrugge; Wim H van Zwam; Yvo B W E M Roos
Journal:  Trials       Date:  2016-11-22       Impact factor: 2.279

10.  Penumbral Imaging-Based Thrombolysis with Tenecteplase Is Feasible up to 24 Hours after Symptom Onset.

Authors:  Mahesh Kate; Robert Wannamaker; Harsha Kamble; Parnian Riaz; Laura C Gioia; Brian Buck; Thomas Jeerakathil; Penelope Smyth; Ashfaq Shuaib; Derek Emery; Kenneth Butcher
Journal:  J Stroke       Date:  2018-01-31       Impact factor: 6.967
  10 in total
  4 in total

1.  Three Days Delayed Recanalization Improved Neurological Function in pMCAO Rats by Increasing M2 Microglia-Possible Involvement of the IL-4R/STAT6/PPARγ Pathway.

Authors:  Ruiqing Kang; Marcin Gamdzyk; Yujie Luo; Hong Tang; Lei Huang; Cameron Lenahan; Desislava Doycheva; Dujuan Li; Jiping Tang; Sheng Tan; John H Zhang
Journal:  Transl Stroke Res       Date:  2022-07-22       Impact factor: 6.800

2.  Deep learning-based identification of acute ischemic core and deficit from non-contrast CT and CTA.

Authors:  Chengyan Wang; Zhang Shi; Ming Yang; Lixiang Huang; Wenxing Fang; Li Jiang; Jing Ding; He Wang
Journal:  J Cereb Blood Flow Metab       Date:  2021-06-08       Impact factor: 6.960

Review 3.  Neuroimaging Markers of Cerebral Small Vessel Disease on Hemorrhagic Transformation and Functional Outcome After Intravenous Thrombolysis in Patients With Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Authors:  Yiqiao Wang; Xiaoting Yan; Jie Zhan; Peiming Zhang; Guangming Zhang; Shuqi Ge; Hao Wen; Lin Wang; Nenggui Xu; Liming Lu
Journal:  Front Aging Neurosci       Date:  2021-07-13       Impact factor: 5.750

4.  Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke.

Authors:  Song Ta; Xianfang Rong; Zhen-Ni Guo; Hang Jin; Peng Zhang; Fenge Li; Zhihuan Li; Lilong Lin; Chenqing Zheng; Qingquan Gu; Yuan Zhang; Wenlan Liu; Yi Yang; Junlei Chang
Journal:  CNS Neurosci Ther       Date:  2020-09-29       Impact factor: 7.035
  4 in total

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