Johannes M Giesinger1, Fanny L C Loth2, Neil K Aaronson3, Juan I Arraras4, Giovanni Caocci5, Fabio Efficace6, Mogens Groenvold7, Marieke van Leeuwen3, Morten Aa Petersen7, John Ramage8, Krzysztof A Tomaszewski9, Teresa Young10, Bernhard Holzner2. 1. University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: johannes.giesinger@i-med.ac.at. 2. University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. 3. Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. 4. Oncology Department, Complejo Hospitalario of Navarra, Pamplona, Spain. 5. Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy. 6. Health Outcomes Research Unit, Italian Group for Adult Hematologic Diseases (GIMEMA) Data Center, Rome, Italy. 7. The Research Unit, Department of Palliative Medicine, Bispebjerg Hospital, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 8. Department of Gastroenterology and Hepatology, Hampshire Hospitals NHS Foundation Trust, Aldermaston Road, Basingstoke RG24 9NA, UK. 9. Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland; Scanmed St. Raphael Hospital, Krakow, Poland. 10. Lynda Jackson Macmillan Centre, East & North Hertfordshire NHS Trust incorporating Mount Vernon Cancer Centre, Northwood, UK.
Abstract
OBJECTIVES: The aim of this article was to establish thresholds for clinical importance (TCIs) for the European Organisation for Research and Treatment of Cancer (EORTC) Computer Adaptive Testing (CAT) Core measure, the new adaptive version of the EORTC QLQ-C30. STUDY DESIGN AND SETTING: For our diagnostic study, we recruited cancer patients with mixed diagnoses and treatments from six European countries. Patients completed the EORTC CAT Core and a questionnaire with anchor items assessing criteria for clinical importance (limitations in everyday life, need for help/care, and worries by the patient/family/partner) for each EORTC CAT Core domain. We used a binary variable summarizing the anchor items for determining TCIs and for calculating the area under the curve (AUC) in receiving operator characteristic analysis as a measure of diagnostic accuracy. RESULTS: Using data from 498 cancer patients (mean age 60.4 years, 55.2% women), we established TCIs for the 14 domains of the EORTC CAT Core. Median AUC across domains was 0.93 (range 0.84-0.94). Median sensitivity and specificity of the TCIs were 0.91 (range 0.80-0.96) and 0.77 (range 0.66-0.84), respectively. TCIs and AUCs were largely consistent across patient groups. CONCLUSION: We have generated TCIs for the 14 functional health and symptom domains of the EORTC CAT Core. The EORTC CAT Core showed high diagnostic accuracy in identifying clinically important symptoms and functional impairments.
OBJECTIVES: The aim of this article was to establish thresholds for clinical importance (TCIs) for the European Organisation for Research and Treatment of Cancer (EORTC) Computer Adaptive Testing (CAT) Core measure, the new adaptive version of the EORTC QLQ-C30. STUDY DESIGN AND SETTING: For our diagnostic study, we recruited cancerpatients with mixed diagnoses and treatments from six European countries. Patients completed the EORTC CAT Core and a questionnaire with anchor items assessing criteria for clinical importance (limitations in everyday life, need for help/care, and worries by the patient/family/partner) for each EORTC CAT Core domain. We used a binary variable summarizing the anchor items for determining TCIs and for calculating the area under the curve (AUC) in receiving operator characteristic analysis as a measure of diagnostic accuracy. RESULTS: Using data from 498 cancerpatients (mean age 60.4 years, 55.2% women), we established TCIs for the 14 domains of the EORTC CAT Core. Median AUC across domains was 0.93 (range 0.84-0.94). Median sensitivity and specificity of the TCIs were 0.91 (range 0.80-0.96) and 0.77 (range 0.66-0.84), respectively. TCIs and AUCs were largely consistent across patient groups. CONCLUSION: We have generated TCIs for the 14 functional health and symptom domains of the EORTC CAT Core. The EORTC CAT Core showed high diagnostic accuracy in identifying clinically important symptoms and functional impairments.
Authors: Emma Lidington; Johannes M Giesinger; Silvie H M Janssen; Suzanne Tang; Sam Beardsworth; Anne-Sophie Darlington; Naureen Starling; Zoltan Szucs; Michael Gonzalez; Anand Sharma; Bhawna Sirohi; Winette T A van der Graaf; Olga Husson Journal: Qual Life Res Date: 2022-04-27 Impact factor: 3.440
Authors: Stephen Clarke; Belinda E Butcher; Andrew J McLachlan; Jeremy D Henson; David Rutolo; Sean Hall; Luis Vitetta Journal: PLoS One Date: 2022-10-14 Impact factor: 3.752