Ashley N Battarbee1, Kartik K Venkatesh2, Sofia Aliaga3, Kim A Boggess2. 1. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina, Chapel Hill, NC, USA. anbattarbee@uabmc.edu. 2. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of North Carolina, Chapel Hill, NC, USA. 3. Department of Pediatrics, Division of Neonatology, University of North Carolina, Chapel Hill, NC, USA.
Abstract
OBJECTIVE: To estimate the association between maternal diabetes and severe neonatal morbidity. STUDY DESIGN: Retrospective cohort study of nonanomalous neonates born 240-416 weeks' gestation from two large multisite U.S. cohorts, Cesarean Registry and Consortium on Safe Labor. The exposure was pregestational versus gestational versus no diabetes. The composite neonatal outcome included respiratory distress syndrome, mechanical ventilation, necrotizing enterocolitis, grade 3-4 intraventricular hemorrhage, and death. Multivariable logistic regression estimated the association between diabetes and neonatal morbidity. RESULT: Of 196,006 eligible neonates, 2993 (1.5%) were born to mothers with pregestational diabetes and 10,549 (5.4%) with gestational diabetes. Pregestational diabetes was associated with higher odds of neonatal morbidity versus gestational diabetes (aOR 2.27, 95% CI 1.95-2.64), as well as no diabetes (aOR 1.96, 95% CI 1.63-2.35). Gestational diabetes was associated with higher odds of neonatal morbidity versus no diabetes (aOR 1.16, 95% CI 1.04-1.30). CONCLUSION: Pregestational and gestational diabetes are risk factors for severe neonatal morbidity.
OBJECTIVE: To estimate the association between maternal diabetes and severe neonatal morbidity. STUDY DESIGN: Retrospective cohort study of nonanomalous neonates born 240-416 weeks' gestation from two large multisite U.S. cohorts, Cesarean Registry and Consortium on Safe Labor. The exposure was pregestational versus gestational versus no diabetes. The composite neonatal outcome included respiratory distress syndrome, mechanical ventilation, necrotizing enterocolitis, grade 3-4 intraventricular hemorrhage, and death. Multivariable logistic regression estimated the association between diabetes and neonatal morbidity. RESULT: Of 196,006 eligible neonates, 2993 (1.5%) were born to mothers with pregestational diabetes and 10,549 (5.4%) with gestational diabetes. Pregestational diabetes was associated with higher odds of neonatal morbidity versus gestational diabetes (aOR 2.27, 95% CI 1.95-2.64), as well as no diabetes (aOR 1.96, 95% CI 1.63-2.35). Gestational diabetes was associated with higher odds of neonatal morbidity versus no diabetes (aOR 1.16, 95% CI 1.04-1.30). CONCLUSION: Pregestational and gestational diabetes are risk factors for severe neonatal morbidity.
Authors: Tyler Schaeffer; Maria F Canizares; Lindley B Wall; Deborah Bohn; Suzanne Steinman; Julie Samora; Mary Claire Manske; Douglas T Hutchinson; Apurva S Shah; Andrea S Bauer Journal: J Hand Surg Glob Online Date: 2022-04-01
Authors: Lynsa M Nguyen; Joel I Omage; Kristen Noble; Kelsey L McNew; Daniel J Moore; David M Aronoff; Ryan S Doster Journal: Am J Reprod Immunol Date: 2021-10-19 Impact factor: 3.886
Authors: Yinon Gilboa; Michał Krekora; Sharon Perlman; Ron Bardin; Eran Kassif; Reuven Achiron; Katarzyna Zych-Krekora; Piotr Kaczmarek; Mariusz Grzesiak; Zvi Kivilevitch Journal: Arch Med Sci Date: 2021-08-04 Impact factor: 3.318
Authors: Ana López-de-Andrés; Napoleón Perez-Farinos; Valentín Hernández-Barrera; María A Palomar-Gallego; David Carabantes-Alarcón; José J Zamorano-León; Javier de Miguel-Diez; Rodrigo Jimenez-Garcia Journal: J Clin Med Date: 2020-02-21 Impact factor: 4.241