| Literature DB >> 31588021 |
Lichun Ma1, Maria O Hernandez2, Yongmei Zhao3, Monika Mehta3, Bao Tran3, Michael Kelly3, Zachary Rae3, Jonathan M Hernandez4, Jeremy L Davis4, Sean P Martin5, David E Kleiner6, Stephen M Hewitt7, Kris Ylaya7, Bradford J Wood8, Tim F Greten9, Xin Wei Wang10.
Abstract
Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid malignancies. Here, we determined the single-cell transcriptomic landscape of liver cancer biospecimens from 19 patients. We found varying degrees of heterogeneity in malignant cells within and between tumors and diverse landscapes of tumor microenvironment (TME). Strikingly, tumors with higher transcriptomic diversity were associated with patient's worse overall survival. We found a link between hypoxia-dependent vascular endothelial growth factor expression in tumor diversity and TME polarization. Moreover, T cells from higher heterogeneous tumors showed lower cytolytic activities. Consistent results were found using bulk genomic and transcriptomic profiles of 765 liver tumors. Our results offer insight into the diverse ecosystem of liver cancer and its impact on patient prognosis. Published by Elsevier Inc.Entities:
Keywords: VEGF; biodiversity; cholangiocarcinoma; hepatocellular carcinoma; liver cancer; microenvironmental reprogramming; single-cell; tumor ecosystem; tumor heterogeneity; tumor microenvironments
Mesh：
Substances：
Year: 2019 PMID： 31588021 PMCID： PMC6801104 DOI： 10.1016/j.ccell.2019.08.007
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743