Erika Ogino1, Jennifer J Manly2, Nicole Schupf3, Richard Mayeux4, Yian Gu5. 1. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA. 2. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. 3. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA. 4. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA. 5. Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Neurology, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: yg2121@cumc.columbia.edu.
Abstract
INTRODUCTION: The associations between self-reported current and past leisure time physical activity (LTPA) and Alzheimer's disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP) study. METHODS: The metabolic equivalent of LTPA energy expenditure was calculated for self-reported current and past LTPA for 1345 older adults. A Cox proportional hazard model was conducted to estimate the association between LTPA (low, middle, and high) and incident AD risk. RESULTS: Comparing high to low level, current and past LTPA were both associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.39 (0.20-0.75) and 0.37 (0.18-0.75), respectively. Compared with "always low," "increased" and "always high" LTPA throughout life were associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.60 (0.36-0.99) and 0.28 (0.08-0.94), respectively. Light- and moderate-intensity LTPA were associated with lower AD risk. DISCUSSION: LTPA both throughout life and later in life are associated with lower risk of AD.
INTRODUCTION: The associations between self-reported current and past leisure time physical activity (LTPA) and Alzheimer's disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP) study. METHODS: The metabolic equivalent of LTPA energy expenditure was calculated for self-reported current and past LTPA for 1345 older adults. A Cox proportional hazard model was conducted to estimate the association between LTPA (low, middle, and high) and incident AD risk. RESULTS: Comparing high to low level, current and past LTPA were both associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.39 (0.20-0.75) and 0.37 (0.18-0.75), respectively. Compared with "always low," "increased" and "always high" LTPA throughout life were associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.60 (0.36-0.99) and 0.28 (0.08-0.94), respectively. Light- and moderate-intensity LTPA were associated with lower AD risk. DISCUSSION: LTPA both throughout life and later in life are associated with lower risk of AD.
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