BACKGROUND: There is evidence of a synergistic interaction between obesity and sedentary lifestyle with respect to diabetes. Although diabetes is a known risk factor for dementia, it is unclear if both diseases have common aetiologies. METHODS: A community-based sample of 1,448 Swedish women, aged 38-60 years and free of diabetes and dementia in 1968, was followed by means of up to 5 examinations spread over 34 years. 9.6% of all women developed diabetes and 11.4% developed dementia (over 40,000 person-years of follow-up for each disease). Cox proportional hazard regression was used to assess the influence of selected risk factors on both diseases, and the relation between diabetes and dementia. RESULTS: Comparing risk factors for incident diabetes and dementia, both diseases showed a synergistic association with obesity combined with a low level of leisure time physical activity [hazard ratio (HR) for interaction = 2.7, 95% confidence interval (CI) = 1.2-6.3 for diabetes and HR = 3.3, 95% CI = 1.1-9.9 for dementia]. Development of diabetes doubled the risk for subsequent dementia (HR = 2.2, 95% CI = 1.1-4.4), which was slightly reduced upon adjustment for common risk factors. CONCLUSIONS: Shared risk factors suggest a similar aetiology for diabetes and dementia and partially explain the association between diseases.
BACKGROUND: There is evidence of a synergistic interaction between obesity and sedentary lifestyle with respect to diabetes. Although diabetes is a known risk factor for dementia, it is unclear if both diseases have common aetiologies. METHODS: A community-based sample of 1,448 Swedish women, aged 38-60 years and free of diabetes and dementia in 1968, was followed by means of up to 5 examinations spread over 34 years. 9.6% of all women developed diabetes and 11.4% developed dementia (over 40,000 person-years of follow-up for each disease). Cox proportional hazard regression was used to assess the influence of selected risk factors on both diseases, and the relation between diabetes and dementia. RESULTS: Comparing risk factors for incident diabetes and dementia, both diseases showed a synergistic association with obesity combined with a low level of leisure time physical activity [hazard ratio (HR) for interaction = 2.7, 95% confidence interval (CI) = 1.2-6.3 for diabetes and HR = 3.3, 95% CI = 1.1-9.9 for dementia]. Development of diabetes doubled the risk for subsequent dementia (HR = 2.2, 95% CI = 1.1-4.4), which was slightly reduced upon adjustment for common risk factors. CONCLUSIONS: Shared risk factors suggest a similar aetiology for diabetes and dementia and partially explain the association between diseases.
Authors: Mark A Espeland; Roberta Diaz Brinton; Christina Hugenschmidt; JoAnn E Manson; Suzanne Craft; Kristine Yaffe; Julie Weitlauf; Leslie Vaughan; Karen C Johnson; Claudia B Padula; Rebecca D Jackson; Susan M Resnick Journal: Diabetes Care Date: 2015-10-20 Impact factor: 19.112
Authors: Monique Chaaya; Kieu Phung; Samir Atweh; Khalil El Asmar; Georges Karam; Rose Mary Khoury; Lilian Ghandour; Husam Ghusn; Sarah Assaad; Martin Prince; Gunhild Waldemar Journal: Prev Med Rep Date: 2017-11-24