| Literature DB >> 31584143 |
D Gallo1, L Mortara2, M B Gariboldi3, S A M Cattaneo4, S Rosetti1, L Gentile1, D M Noonan2,5, P Premoli1, C Cusini1, M L Tanda1, L Bartalena6, E Piantanida7.
Abstract
The main role of vitamin D is to control mineral homeostasis. However, recent studies suggested the existence of a number of extraskeletal effects. Among the latter, preclinical studies provided consistent data on the involvement of vitamin D in innate and adaptive immunity and autoimmunity. Molecular biology studies showed that both vitamin D receptor and vitamin D enzymatic complexes are expressed in a large number of cells and tissues unrelated to mineral homeostasis. In contrast, only a few randomized clinical trials in humans investigated the possible role of vitamin D in the prevention or treatment of immunological disorders. In this regard, low serum vitamin D levels have been reported in observational trials in human autoimmune disorders. The aim of the present paper was to review the potential implications of vitamin D in immune modulation, with special focus on thyroid autoimmune disorders.Entities:
Keywords: Autoimmunity; Graves’ diseases; Hashimoto’s thyroiditis; Vitamin D
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Year: 2019 PMID： 31584143 DOI： 10.1007/s40618-019-01123-5
Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 5.467