| Literature DB >> 20511049 |
Sylvia Christakos1, Dare V Ajibade, Puneet Dhawan, Adam J Fechner, Leila J Mady.
Abstract
The biologically active metabolite of vitamin D, 1,25(OH)(2)D(3), affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH)(2)D(3). The role of extrarenal 1alpha(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20511049 PMCID： PMC2879391 DOI： 10.1016/j.ecl.2010.02.002
Source DB: PubMed Journal: Endocrinol Metab Clin North Am ISSN： 0889-8529 Impact factor: 4.741