Literature DB >> 31582848

RNA-modifying enzymes and their function in a chromatin context.

Konstantinos Tzelepis1, Oliver Rausch2, Tony Kouzarides3.   

Abstract

Exciting research has connected specific RNA modifications to chromatin, providing evidence for co-transcriptional deposition and function in gene regulation. Here we review insights gained from studying the co-transcriptional roles of RNA modifications, and their influence in normal and disease contexts. We also discuss how the availability of novel technical approaches could raise the translational potential of targeting RNA-modifying enzymes for the treatment of disease.

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Year:  2019        PMID： 31582848      PMCID： PMC7613430          DOI： 10.1038/s41594-019-0312-0

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   18.361


  108 in total

Review 1.  Epigenetic protein families: a new frontier for drug discovery.

Authors:  Cheryl H Arrowsmith; Chas Bountra; Paul V Fish; Kevin Lee; Matthieu Schapira
Journal:  Nat Rev Drug Discov       Date:  2012-04-13       Impact factor: 84.694

2.  Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

Authors:  Shay Geula; Sharon Moshitch-Moshkovitz; Dan Dominissini; Abed AlFatah Mansour; Nitzan Kol; Mali Salmon-Divon; Vera Hershkovitz; Eyal Peer; Nofar Mor; Yair S Manor; Moshe Shay Ben-Haim; Eran Eyal; Sharon Yunger; Yishay Pinto; Diego Adhemar Jaitin; Sergey Viukov; Yoach Rais; Vladislav Krupalnik; Elad Chomsky; Mirie Zerbib; Itay Maza; Yoav Rechavi; Rada Massarwa; Suhair Hanna; Ido Amit; Erez Y Levanon; Ninette Amariglio; Noam Stern-Ginossar; Noa Novershtern; Gideon Rechavi; Jacob H Hanna
Journal:  Science       Date:  2015-01-01       Impact factor: 47.728

3.  Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA.

Authors:  Schraga Schwartz; Douglas A Bernstein; Maxwell R Mumbach; Marko Jovanovic; Rebecca H Herbst; Brian X León-Ricardo; Jesse M Engreitz; Mitchell Guttman; Rahul Satija; Eric S Lander; Gerald Fink; Aviv Regev
Journal:  Cell       Date:  2014-09-11       Impact factor: 41.582

4.  Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.

Authors:  Ping Wang; Katelyn A Doxtader; Yunsun Nam
Journal:  Mol Cell       Date:  2016-06-30       Impact factor: 17.970

5.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

Authors:  Fiona M Behan; Francesco Iorio; Gabriele Picco; Kosuke Yusa; Mathew J Garnett; Emanuel Gonçalves; Charlotte M Beaver; Giorgia Migliardi; Rita Santos; Yanhua Rao; Francesco Sassi; Marika Pinnelli; Rizwan Ansari; Sarah Harper; David Adam Jackson; Rebecca McRae; Rachel Pooley; Piers Wilkinson; Dieudonne van der Meer; David Dow; Carolyn Buser-Doepner; Andrea Bertotti; Livio Trusolino; Euan A Stronach; Julio Saez-Rodriguez
Journal:  Nature       Date:  2019-04-10       Impact factor: 49.962

6.  Enhanced detection of post-transcriptional modifications using a mass-exclusion list strategy for RNA modification mapping by LC-MS/MS.

Authors:  Xiaoyu Cao; Patrick A Limbach
Journal:  Anal Chem       Date:  2015-07-28       Impact factor: 6.986

7.  Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.

Authors:  Bastian Linder; Anya V Grozhik; Anthony O Olarerin-George; Cem Meydan; Christopher E Mason; Samie R Jaffrey
Journal:  Nat Methods       Date:  2015-06-29       Impact factor: 28.547

8.  tRNA base methylation identification and quantification via high-throughput sequencing.

Authors:  Wesley C Clark; Molly E Evans; Dan Dominissini; Guanqun Zheng; Tao Pan
Journal:  RNA       Date:  2016-09-09       Impact factor: 4.942

9.  Single-base mapping of m6A by an antibody-independent method.

Authors:  Zhang Zhang; Li-Qian Chen; Yu-Li Zhao; Cai-Guang Yang; Ian A Roundtree; Zijie Zhang; Jian Ren; Wei Xie; Chuan He; Guan-Zheng Luo
Journal:  Sci Adv       Date:  2019-07-03       Impact factor: 14.136

10.  Identification of direct targets and modified bases of RNA cytosine methyltransferases.

Authors:  Vahid Khoddami; Bradley R Cairns
Journal:  Nat Biotechnol       Date:  2013-04-21       Impact factor: 54.908
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  7 in total

1.  Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity.

Authors:  Gillian Houlihan; Sebastian Arangundy-Franklin; Benjamin T Porebski; Nithya Subramanian; Alexander I Taylor; Philipp Holliger
Journal:  Nat Chem       Date:  2020-07-20       Impact factor: 24.427

Review 2.  RNA Epigenetics: Fine-Tuning Chromatin Plasticity and Transcriptional Regulation, and the Implications in Human Diseases.

Authors:  Amber Willbanks; Shaun Wood; Jason X Cheng
Journal:  Genes (Basel)       Date:  2021-04-22       Impact factor: 4.096

3.  Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons.

Authors:  Simona Selberg; Li-Ying Yu; Olesja Bondarenko; Esko Kankuri; Neinar Seli; Vera Kovaleva; Koit Herodes; Mart Saarma; Mati Karelson
Journal:  Int J Mol Sci       Date:  2021-04-26       Impact factor: 5.923

Review 4.  Brain on food: The neuroepigenetics of nutrition.

Authors:  Anoumid Vaziri; Monica Dus
Journal:  Neurochem Int       Date:  2021-06-13       Impact factor: 4.297

5.  Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.

Authors:  Eliza Yankova; Wesley Blackaby; Mark Albertella; Justyna Rak; Etienne De Braekeleer; Georgia Tsagkogeorga; Ewa S Pilka; Demetrios Aspris; Dan Leggate; Alan G Hendrick; Natalie A Webster; Byron Andrews; Richard Fosbeary; Patrick Guest; Nerea Irigoyen; Maria Eleftheriou; Malgorzata Gozdecka; Joao M L Dias; Andrew J Bannister; Binje Vick; Irmela Jeremias; George S Vassiliou; Oliver Rausch; Konstantinos Tzelepis; Tony Kouzarides
Journal:  Nature       Date:  2021-04-26       Impact factor: 69.504

6.  Predicting genes associated with RNA methylation pathways using machine learning.

Authors:  Hendrik Weisser; Namshik Han; Georgia Tsagkogeorga; Helena Santos-Rosa; Andrej Alendar; Dan Leggate; Oliver Rausch; Tony Kouzarides
Journal:  Commun Biol       Date:  2022-08-25

Review 7.  Methyltransferases in the Pathogenesis of Keratinocyte Cancers.

Authors:  Eun Kyung Ko; Brian C Capell
Journal:  Cancers (Basel)       Date:  2021-07-07       Impact factor: 6.639
  7 in total

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