Literature DB >> 31582847

Bromodomain biology and drug discovery.

Nilesh Zaware1, Ming-Ming Zhou2.   

Abstract

The bromodomain (BrD) is a conserved structural module found in chromatin- and transcription-associated proteins that acts as the primary reader for acetylated lysine residues. This basic activity endows BrD proteins with versatile functions in the regulation of protein-protein interactions mediating chromatin-templated gene transcription, DNA recombination, replication and repair. Consequently, BrD proteins are involved in the pathogenesis of numerous human diseases. In this Review, we highlight our current understanding of BrD biology, and discuss the latest development of small-molecule inhibitors targeting BrDs as emerging epigenetic therapies for cancer and inflammatory disorders.

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Year:  2019        PMID： 31582847      PMCID： PMC6984398          DOI： 10.1038/s41594-019-0309-8

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  112 in total

1.  The language of covalent histone modifications.

Authors:  B D Strahl; C D Allis
Journal:  Nature       Date:  2000-01-06       Impact factor: 49.962

2.  The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins.

Authors:  S R Haynes; C Dollard; F Winston; S Beck; J Trowsdale; I B Dawid
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

3.  ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.

Authors:  V G ALLFREY; R FAULKNER; A E MIRSKY
Journal:  Proc Natl Acad Sci U S A       Date:  1964-05       Impact factor: 11.205

4.  Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification.

Authors:  Minjia Tan; Hao Luo; Sangkyu Lee; Fulai Jin; Jeong Soo Yang; Emilie Montellier; Thierry Buchou; Zhongyi Cheng; Sophie Rousseaux; Nisha Rajagopal; Zhike Lu; Zhen Ye; Qin Zhu; Joanna Wysocka; Yang Ye; Saadi Khochbin; Bing Ren; Yingming Zhao
Journal:  Cell       Date:  2011-09-16       Impact factor: 41.582

5.  Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.

Authors:  J E Brownell; J Zhou; T Ranalli; R Kobayashi; D G Edmondson; S Y Roth; C D Allis
Journal:  Cell       Date:  1996-03-22       Impact factor: 41.582

6.  Structure and ligand of a histone acetyltransferase bromodomain.

Authors:  C Dhalluin; J E Carlson; L Zeng; C He; A K Aggarwal; M M Zhou
Journal:  Nature       Date:  1999-06-03       Impact factor: 49.962

7.  Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines.

Authors:  M H Kuo; J E Brownell; R E Sobel; T A Ranalli; R G Cook; D G Edmondson; S Y Roth; C D Allis
Journal:  Nature       Date:  1996-09-19       Impact factor: 49.962

8.  Suppression of inflammation by a synthetic histone mimic.

Authors:  Edwige Nicodeme; Kate L Jeffrey; Uwe Schaefer; Soren Beinke; Scott Dewell; Chun-Wa Chung; Rohit Chandwani; Ivan Marazzi; Paul Wilson; Hervé Coste; Julia White; Jorge Kirilovsky; Charles M Rice; Jose M Lora; Rab K Prinjha; Kevin Lee; Alexander Tarakhovsky
Journal:  Nature       Date:  2010-11-10       Impact factor: 49.962

9.  A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.

Authors:  J Taunton; C A Hassig; S L Schreiber
Journal:  Science       Date:  1996-04-19       Impact factor: 47.728

10.  Selective inhibition of BET bromodomains.

Authors:  Panagis Filippakopoulos; Jun Qi; Sarah Picaud; Yao Shen; William B Smith; Oleg Fedorov; Elizabeth M Morse; Tracey Keates; Tyler T Hickman; Ildiko Felletar; Martin Philpott; Shonagh Munro; Michael R McKeown; Yuchuan Wang; Amanda L Christie; Nathan West; Michael J Cameron; Brian Schwartz; Tom D Heightman; Nicholas La Thangue; Christopher A French; Olaf Wiest; Andrew L Kung; Stefan Knapp; James E Bradner
Journal:  Nature       Date:  2010-09-24       Impact factor: 49.962
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  51 in total

1.  From Circuits to Chromatin: The Emerging Role of Epigenetics in Mental Health.

Authors:  Philipp Mews; Erin S Calipari; Jeremy Day; Mary Kay Lobo; Timothy Bredy; Ted Abel
Journal:  J Neurosci       Date:  2021-01-14       Impact factor: 6.167

2.  Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.

Authors:  Jorden A Johnson; Christos A Nicolaou; Steven E Kirberger; Anil K Pandey; Haitao Hu; William C K Pomerantz
Journal:  ACS Med Chem Lett       Date:  2019-11-22       Impact factor: 4.345

Review 3.  Targeting epigenetic protein-protein interactions with small-molecule inhibitors.

Authors:  Brian M Linhares; Jolanta Grembecka; Tomasz Cierpicki
Journal:  Future Med Chem       Date:  2020-06-19       Impact factor: 3.808

4.  Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer.

Authors:  Donglei Ji; Guanglei Shang; Enwei Wei; Yanjie Jia; Chunyu Wang; Qiang Zhang; Lei Zeng
Journal:  Oncogene       Date:  2022-05-05       Impact factor: 9.867

5.  Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.

Authors:  Aliaksandra Radzisheuskaya; Pavel V Shliaha; Vasily V Grinev; Daria Shlyueva; Helene Damhofer; Richard Koche; Vladimir Gorshkov; Sergey Kovalchuk; Yingqian Zhan; Keli L Rodriguez; Andrea L Johnstone; Michael-C Keogh; Ronald C Hendrickson; Ole N Jensen; Kristian Helin
Journal:  Mol Cell       Date:  2021-03-02       Impact factor: 17.970

Review 6.  The language of chromatin modification in human cancers.

Authors:  Shuai Zhao; C David Allis; Gang Greg Wang
Journal:  Nat Rev Cancer       Date:  2021-05-17       Impact factor: 60.716

7.  Phase Separation and Histone Epigenetics in Genome Regulation.

Authors:  Reed E S Harrison; Kegui Weng; Yingxiao Wang; Qin Peng
Journal:  Curr Opin Solid State Mater Sci       Date:  2020-12-23       Impact factor: 11.354

8.  PD-L1 is upregulated via BRD2 in head and neck squamous cell carcinoma models of acquired cetuximab resistance.

Authors:  Neil E Bhola; Christian Njatcha; Lanlin Hu; Eliot D Lee; Jamie V Shiah; Mi-Ok Kim; Daniel E Johnson; Jennifer R Grandis
Journal:  Head Neck       Date:  2021-08-03       Impact factor: 3.147

Review 9.  Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges.

Authors:  Kristine E Yoder; Anthony J Rabe; Richard Fishel; Ross C Larue
Journal:  Front Mol Biosci       Date:  2021-05-12

10.  Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response.

Authors:  Chun-Shan Liu; Reka Toth; Ali Bakr; Ashish Goyal; Md Saiful Islam; Kersten Breuer; Anand Mayakonda; Yu-Yu Lin; Peter Stepper; Tomasz P Jurkowski; Marlon R Veldwijk; Elena Sperk; Carsten Herskind; Pavlo Lutsik; Dieter Weichenhan; Christoph Plass; Peter Schmezer; Odilia Popanda
Journal:  Cancers (Basel)       Date:  2021-05-18       Impact factor: 6.639
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