| Literature DB >> 31582063 |
Tomasz Machałowski1, Marcin Wysokowski2, Sonia Żółtowska-Aksamitowska2, Nicole Bechmann3, Björn Binnewerg4, Mario Schubert4, Kaomei Guan4, Stefan R Bornstein5, Katarzyna Czaczyk6, Oleg Pokrovsky7, Michael Kraft8, Martin Bertau8, Christian Schimpf9, David Rafaja9, Mikhail Tsurkan10, Roberta Galli11, Heike Meissner12, Iaroslav Petrenko13, Andriy Fursov13, Alona Voronkina14, Marek Figlerowicz15, Yvonne Joseph13, Teofil Jesionowski16, Hermann Ehrlich17.
Abstract
Diverse fields of modern technology and biomedicine can benefit from the application of ready-to-use chitin-based scaffolds. In this work we show for the first time the applicability of tubular and porous chitin from Caribena versicolor spiders as a scaffold for the development of an effective CuO/Cu(OH)2 catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AM), and as a scaffold for the tissue engineering of selected cells. The formation of CuO/Cu(OH)2 phases on and within the chitinous tubes leads to a hybrid material with excellent catalytic performance with respect to the reduction of p-nitrophenol. On the other hand, experimental results provide for the first time strong evidence for the biocompatibility of spider chitin with different cell types, a human progenitor cell line (hPheo1), as well as cardiomyocytes differentiated from induced pluripotent stem cells (iPSC-CMs) that were cultured on a tube-like scaffold.Entities:
Keywords: biocompatibility; biopolymers; catalyst; chitin; human cells; spider molt cuticle; tissue engineering
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Year: 2019 PMID： 31582063 DOI： 10.1016/j.carbpol.2019.115301
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381