Literature DB >> 31576061

Utilising Genetically-Informed Research Designs to Better Understand Family Processes and Child Development: Implications for Adoption and Foster Care Focused Interventions.

R Sellers1,2, A F Smith1, L D Leve3, E Nixon4, T Cane5, J A Cassell6, G T Harold1,2,4.   

Abstract

Understanding the interplay between genetic factors and family environmental processes (e.g., inter-parental relationship quality, positive versus negative parenting practices) and children's mental health (e.g., anxiety, depression, conduct problems, ADHD) in the contexts of adoption and foster-care research and practice is critical for effective prevention and intervention programme development. Whilst evidence highlights the importance of family environmental processes for the mental health and well-being of children in adoption and foster care, there is relatively limited evidence of effective interventions specifically for these families. Additionally, family-based interventions not specific to the context of adoption and foster-care typically show small to medium effects, and even where interventions are efficacious, not all children benefit. One explanation for why interventions may not work well for some is that responses to intervention may be influenced by an individual's genetic make-up. This paper summarises how genetically-informed research designs can help disentangle genetic from environmental processes underlying psychopathology outcomes for children, and how this evidence can provide improved insights into the development of more effective preventative intervention targets for adoption and foster-care families. We discuss current difficulties in translating behavioural genetics research to prevention science, and provide recommendations to bridge the gap between behavioural genetics research and prevention science, with lessons for adoption and foster-care research and practice.

Entities:  

Keywords:  adoption; child; family; foster-care; genetically-informed research designs; intervention; mental health; prevention science; quantitative genetics

Year:  2019        PMID: 31576061      PMCID: PMC6771282          DOI: 10.1177/0308575919866526

Source DB:  PubMed          Journal:  Adopt Foster        ISSN: 0308-5759


  75 in total

1.  Refining Intervention Targets in Family-Based Research: Lessons From Quantitative Behavioral Genetics.

Authors:  Leslie D Leve; Gordon T Harold; Xiaojia Ge; Jenae M Neiderhiser; Gerald Patterson
Journal:  Perspect Psychol Sci       Date:  2010-09

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3.  Angry responses to infant challenges: parent, marital, and child genetic factors associated with harsh parenting.

Authors:  Nastassia Hajal; Jenae Neiderhiser; Ginger Moore; Leslie Leve; Daniel Shaw; Gordon Harold; Laura Scaramella; Jody Ganiban; David Reiss
Journal:  Child Dev       Date:  2015-02-02

4.  The impact of parent behavior-management training on child depressive symptoms.

Authors:  Carolyn Webster-Stratton; Keith C Herman
Journal:  J Couns Psychol       Date:  2008-10

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Authors:  Francis S Collins; Harold Varmus
Journal:  N Engl J Med       Date:  2015-01-30       Impact factor: 91.245

6.  Family conflict interacts with genetic liability in predicting childhood and adolescent depression.

Authors:  Frances Rice; Gordon T Harold; Katherine H Shelton; Anita Thapar
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2006-07       Impact factor: 8.829

Review 7.  Practitioner review: Children in foster care--vulnerabilities and evidence-based interventions that promote resilience processes.

Authors:  Leslie D Leve; Gordon T Harold; Patricia Chamberlain; John A Landsverk; Philip A Fisher; Panos Vostanis
Journal:  J Child Psychol Psychiatry       Date:  2012-08-06       Impact factor: 8.982

8.  Genetics of obesity in adult adoptees and their biological siblings.

Authors:  T I Sørensen; R A Price; A J Stunkard; F Schulsinger
Journal:  BMJ       Date:  1989-01-14

9.  Genotype-environment correlations in late childhood and early adolescence: antisocial behavioral problems and coercive parenting.

Authors:  T G O'Connor; K Deater-Deckard; D Fulker; M Rutter; R Plomin
Journal:  Dev Psychol       Date:  1998-09

10.  Nature X nurture: genetic vulnerabilities interact with physical maltreatment to promote conduct problems.

Authors:  Sara R Jaffee; Avshalom Caspi; Terrie E Moffitt; Kenneth A Dodge; Michael Rutter; Alan Taylor; Lucy A Tully
Journal:  Dev Psychopathol       Date:  2005
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