Mary E Ingle1, Deborah Watkins1, Zaira Rosario2, Carmen M Vélez Vega2, Gredia Huerta-Montanez3, Antonia M Calafat4, Maria Ospina4, José F Cordero5, Akram Alshawabkeh6, John D Meeker7. 1. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. 2. University of Puerto Rico Graduate School of Public Health, UPR Medical Sciences Campus, PO Box 365067, San Juan, PR, 00936-5067, USA. 3. Northeastern University, 110 Forsyth St, Boston, MA, 02115, USA. 4. Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F17, Atlanta, GA, 30341, USA. 5. Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, USA. 6. College of Engineering, Northeastern University, 110 Forsyth St, Boston, MA, 02115, USA. 7. Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA. Electronic address: meekerj@umich.edu.
Abstract
BACKGROUND: Organophosphate esters (OPEs) are widely detected among U.S. pregnant women. OPEs, some of which are present in nail polish, have been associated with adverse reproductive health outcomes. More research is needed to investigate associations with OPEs and personal care products (PCP) use. METHODS: Pregnant women (18-40 years) were recruited from two hospitals and five prenatal clinics in Northern Puerto Rico (n = 148 women) between 2011 and 2015. Concentrations of bis(2-chloroethyl) phosphate (BCEtP), bis(1-chloro-2-propyl) phosphate (BCPP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), di-n-butyl phosphate (DNBP), di-benzyl phosphate (DBzP), di-cresyl phosphate (DCP), DPHP, and 2,3,4,5-tetrabromobenzoic acid (TBBA) were measured twice during pregnancy. Participants completed questionnaires on PCP and household products (HP) use. Associations among products and metabolite concentrations (n = 296 observations) were assessed using linear mixed models. RESULTS: BCEtP, BCPP, BDCPP and DPHP were detected frequently (≥77%). Correlations among metabolites (0.16 ≤ r ≤ 0.35) and Intraclass correlation coefficients (ICCs) (0.03 ≤ ICC≤0.34) were weak-to-moderate. Suntan lotion was associated with a 110% increase in BDCPP. DPHP increased with perfume (51%) and nail polish (49%) use. BCPP increased 46% with pesticide use in home. CONCLUSION: Biomarkers of OPEs were often detected among pregnant women. Associations with PCP and HP use suggest OPEs may be used in such products, specifically in perfume and nail polish. Further investigation into these products is warranted.
BACKGROUND:Organophosphate esters (OPEs) are widely detected among U.S. pregnant women. OPEs, some of which are present in nail polish, have been associated with adverse reproductive health outcomes. More research is needed to investigate associations with OPEs and personal care products (PCP) use. METHODS: Pregnant women (18-40 years) were recruited from two hospitals and five prenatal clinics in Northern Puerto Rico (n = 148 women) between 2011 and 2015. Concentrations of bis(2-chloroethyl) phosphate (BCEtP), bis(1-chloro-2-propyl) phosphate (BCPP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), di-n-butyl phosphate (DNBP), di-benzyl phosphate (DBzP), di-cresyl phosphate (DCP), DPHP, and 2,3,4,5-tetrabromobenzoic acid (TBBA) were measured twice during pregnancy. Participants completed questionnaires on PCP and household products (HP) use. Associations among products and metabolite concentrations (n = 296 observations) were assessed using linear mixed models. RESULTS:BCEtP, BCPP, BDCPP and DPHP were detected frequently (≥77%). Correlations among metabolites (0.16 ≤ r ≤ 0.35) and Intraclass correlation coefficients (ICCs) (0.03 ≤ ICC≤0.34) were weak-to-moderate. Suntan lotion was associated with a 110% increase in BDCPP. DPHP increased with perfume (51%) and nail polish (49%) use. BCPP increased 46% with pesticide use in home. CONCLUSION: Biomarkers of OPEs were often detected among pregnant women. Associations with PCP and HP use suggest OPEs may be used in such products, specifically in perfume and nail polish. Further investigation into these products is warranted.
Authors: Katerina Kademoglou; Fuchao Xu; Juan Antonio Padilla-Sanchez; Line Småstuen Haug; Adrian Covaci; Chris D Collins Journal: Environ Int Date: 2017-02-09 Impact factor: 9.621
Authors: Emma Mendelsohn; Audrey Hagopian; Kate Hoffman; Craig M Butt; Amelia Lorenzo; Johanna Congleton; Thomas F Webster; Heather M Stapleton Journal: Environ Int Date: 2015-10-18 Impact factor: 9.621
Authors: Chang He; Karin English; Christine Baduel; Phong Thai; Paul Jagals; Robert S Ware; Yan Li; Xianyu Wang; Peter D Sly; Jochen F Mueller Journal: Environ Res Date: 2018-03-20 Impact factor: 6.498
Authors: Heather M Stapleton; Susan Klosterhaus; Alex Keller; P Lee Ferguson; Saskia van Bergen; Ellen Cooper; Thomas F Webster; Arlene Blum Journal: Environ Sci Technol Date: 2011-05-18 Impact factor: 9.028
Authors: Kate Hoffman; Craig M Butt; Thomas F Webster; Emma V Preston; Stephanie C Hammel; Colleen Makey; Amelia M Lorenzo; Ellen M Cooper; Courtney Carignan; John D Meeker; Russ Hauser; Adelheid Soubry; Susan K Murphy; Thomas M Price; Cathrine Hoyo; Emma Mendelsohn; Johanna Congleton; Julie L Daniels; Heather M Stapleton Journal: Environ Sci Technol Lett Date: 2017-02-08
Authors: Courtney C Carignan; Lidia Mínguez-Alarcón; Craig M Butt; Paige L Williams; John D Meeker; Heather M Stapleton; Thomas L Toth; Jennifer B Ford; Russ Hauser Journal: Environ Health Perspect Date: 2017-08-25 Impact factor: 9.031
Authors: Mary E Ingle; Deborah Watkins; Zaira Rosario; Carmen M VélezVega; Antonia M Calafat; Maria Ospina; Kelly K Ferguson; José F Cordero; Akram Alshawabkeh; John D Meeker Journal: Sci Total Environ Date: 2019-11-04 Impact factor: 7.963
Authors: Lydia M Louis; Lesliam Quirós-Alcalá; Jordan R Kuiper; Gregory Diette; Nadia N Hansel; Meredith C McCormack; John D Meeker; Jessie P Buckley Journal: Environ Res Date: 2022-03-25 Impact factor: 8.431
Authors: Giehae Choi; Alexander P Keil; Gro D Villanger; David B Richardson; Julie L Daniels; Kate Hoffman; Amrit K Sakhi; Cathrine Thomsen; Amy H Herring; Samantha S M Drover; Rachel Nethery; Heidi Aase; Stephanie M Engel Journal: Sci Total Environ Date: 2021-03-24 Impact factor: 10.753
Authors: Emma V Preston; Marissa Chan; Katerina Nozhenko; Andrea Bellavia; Marissa C Grenon; David E Cantonwine; Thomas F McElrath; Tamarra James-Todd Journal: Environ Res Date: 2021-05-03 Impact factor: 8.431
Authors: Jordan R Kuiper; Heather M Stapleton; Marsha Wills-Karp; Xiaobin Wang; Irina Burd; Jessie P Buckley Journal: Environ Health Date: 2020-05-24 Impact factor: 5.984
Authors: Jessie P Buckley; Jordan R Kuiper; Deborah H Bennett; Emily S Barrett; Tracy Bastain; Carrie V Breton; Sridhar Chinthakindi; Anne L Dunlop; Shohreh F Farzan; Julie B Herbstman; Margaret R Karagas; Carmen J Marsit; John D Meeker; Rachel Morello-Frosch; Thomas G O'Connor; Megan E Romano; Susan Schantz; Rebecca J Schmidt; Deborah J Watkins; Hongkai Zhu; Edo D Pellizzari; Kurunthachalam Kannan; Tracey J Woodruff Journal: Environ Sci Technol Date: 2022-05-10 Impact factor: 11.357
Authors: Pat E Rasmussen; Cariton Kubwabo; H David Gardner; Christine Levesque; Suzanne Beauchemin Journal: Int J Environ Res Public Health Date: 2022-08-19 Impact factor: 4.614
Authors: P A Bommarito; B M Welch; A P Keil; G P Baker; D E Cantonwine; T F McElrath; K K Ferguson Journal: Environ Health Date: 2021-06-10 Impact factor: 5.984