Literature DB >> 31570389

The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.

Francesca Gianni1, Laura Belver1, Adolfo Ferrando1,2,3.   

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2020        PMID： 31570389      PMCID： PMC7050584          DOI： 10.1101/cshperspect.a035246

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  330 in total

1.  Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.

Authors:  Yuichi Wakabayashi; Hisami Watanabe; Jun Inoue; Naoki Takeda; Jun Sakata; Yukio Mishima; Jiro Hitomi; Takashi Yamamoto; Masanori Utsuyama; Ohtsura Niwa; Shinichi Aizawa; Ryo Kominami
Journal:  Nat Immunol       Date:  2003-04-28       Impact factor: 25.606

2.  The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2).

Authors:  Stefan Nagel; Maren Kaufmann; Hans G Drexler; Roderick A F MacLeod
Journal:  Cancer Res       Date:  2003-09-01       Impact factor: 12.701

3.  Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.

Authors:  Shannon L Maude; Sibasish Dolai; Cristina Delgado-Martin; Tiffaney Vincent; Alissa Robbins; Arthavan Selvanathan; Theresa Ryan; Junior Hall; Andrew C Wood; Sarah K Tasian; Stephen P Hunger; Mignon L Loh; Charles G Mullighan; Brent L Wood; Michelle L Hermiston; Stephan A Grupp; Richard B Lock; David T Teachey
Journal:  Blood       Date:  2015-02-02       Impact factor: 22.113

4.  Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

Authors:  Christopher A G Booth; Nikolaos Barkas; Wen Hao Neo; Hanane Boukarabila; Elizabeth J Soilleux; George Giotopoulos; Noushin Farnoud; Alice Giustacchini; Neil Ashley; Joana Carrelha; Lauren Jamieson; Deborah Atkinson; Tiphaine Bouriez-Jones; Rab K Prinjha; Thomas A Milne; David T Teachey; Elli Papaemmanuil; Brian J P Huntly; Sten Eirik W Jacobsen; Adam J Mead
Journal:  Cancer Cell       Date:  2018-02-12       Impact factor: 31.743

5.  Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.

Authors:  Roger A Habets; Charles E de Bock; Lutgarde Serneels; Inge Lodewijckx; Delphine Verbeke; David Nittner; Rajeshwar Narlawar; Sofie Demeyer; James Dooley; Adrian Liston; Tom Taghon; Jan Cools; Bart de Strooper
Journal:  Sci Transl Med       Date:  2019-05-29       Impact factor: 17.956

6.  Molecular cytogenetic and clinical findings in ETV6/ABL1-positive leukemia.

Authors:  H Van Limbergen; H B Beverloo; E van Drunen; A Janssens; K Hählen; B Poppe; N Van Roy; P Marynen; A De Paepe; R Slater; F Speleman
Journal:  Genes Chromosomes Cancer       Date:  2001-03       Impact factor: 5.006

7.  The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling.

Authors:  Alena Malyukova; Takeaki Dohda; Natalie von der Lehr; Shahab Akhoondi; Shahab Akhondi; Martin Corcoran; Mats Heyman; Charles Spruck; Dan Grandér; Urban Lendahl; Olle Sangfelt
Journal:  Cancer Res       Date:  2007-06-15       Impact factor: 12.701

8.  Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95.

Authors:  Anja Möricke; Alfred Reiter; Martin Zimmermann; Helmut Gadner; Martin Stanulla; Michael Dördelmann; Lutz Löning; Rita Beier; Wolf-Dieter Ludwig; Richard Ratei; Jochen Harbott; Joachim Boos; Georg Mann; Felix Niggli; Andreas Feldges; Günter Henze; Karl Welte; Jörn-Dirk Beck; Thomas Klingebiel; Charlotte Niemeyer; Felix Zintl; Udo Bode; Christian Urban; Helmut Wehinger; Dietrich Niethammer; Hansjörg Riehm; Martin Schrappe
Journal:  Blood       Date:  2008-02-19       Impact factor: 22.113

9.  The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

Authors:  Emmanuelle Clappier; Wendy Cuccuini; Anna Kalota; Antoine Crinquette; Jean-Michel Cayuela; Willem A Dik; Anton W Langerak; Bertrand Montpellier; Bertrand Nadel; Pierre Walrafen; Olivier Delattre; Alain Aurias; Thierry Leblanc; Hervé Dombret; Alan M Gewirtz; André Baruchel; Francois Sigaux; Jean Soulier
Journal:  Blood       Date:  2007-04-23       Impact factor: 22.113

10.  Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

Authors:  V Stambolic; A Suzuki; J L de la Pompa; G M Brothers; C Mirtsos; T Sasaki; J Ruland; J M Penninger; D P Siderovski; T W Mak
Journal:  Cell       Date:  1998-10-02       Impact factor: 41.582
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  5 in total

Review 1.  Molecular markers in ALL: Clinical implications.

Authors:  Shunsuke Kimura; Charles G Mullighan
Journal:  Best Pract Res Clin Haematol       Date:  2020-06-07       Impact factor: 3.020

2.  B7-H6 is a new potential biomarker and therapeutic target of T-lymphoblastic lymphoma.

Authors:  Lei Yuan; Lu Sun; Siyuan Yang; Xin Chen; Jing Wang; Hongmei Jing; Yu Zhao; Xiaoyan Ke
Journal:  Ann Transl Med       Date:  2021-02

3.  PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis.

Authors:  E G Garcia; A Veloso; M L Oliveira; J R Allen; S Loontiens; D Brunson; D Do; C Yan; R Morris; S Iyer; S P Garcia; N Iftimia; W Van Loocke; F Matthijssens; K McCarthy; J T Barata; F Speleman; T Taghon; A Gutierrez; P Van Vlierberghe; W Haas; J S Blackburn; D M Langenau
Journal:  Leukemia       Date:  2020-06-30       Impact factor: 11.528

4.  Long noncoding RNA endogenous bornavirus-like nucleoprotein acts as an oncogene by regulating microRNA-655-3p expression in T-cell acute lymphoblastic leukemia.

Authors:  Jinhua Yang; Yingying Yang
Journal:  Bioengineered       Date:  2022-03       Impact factor: 3.269

5.  Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia.

Authors:  Lindsey E Montefiori; Sonja Bendig; Zhaohui Gu; Xiaolong Chen; Petri Pölönen; Xiaotu Ma; Alex Murison; Andy Zeng; Laura Garcia-Prat; Kirsten Dickerson; Ilaria Iacobucci; Sherif Abdelhamed; Ryan Hiltenbrand; Paul E Mead; Cyrus M Mehr; Beisi Xu; Zhongshan Cheng; Ti-Cheng Chang; Tamara Westover; Jing Ma; Anna Stengel; Shunsuke Kimura; Chunxu Qu; Marcus B Valentine; Marissa Rashkovan; Selina Luger; Mark R Litzow; Jacob M Rowe; Monique L den Boer; Victoria Wang; Jun Yin; Steven M Kornblau; Stephen P Hunger; Mignon L Loh; Ching-Hon Pui; Wenjian Yang; Kristine R Crews; Kathryn G Roberts; Jun J Yang; Mary V Relling; William E Evans; Wendy Stock; Elisabeth M Paietta; Adolfo A Ferrando; Jinghui Zhang; Wolfgang Kern; Torsten Haferlach; Gang Wu; John E Dick; Jeffery M Klco; Claudia Haferlach; Charles G Mullighan
Journal:  Cancer Discov       Date:  2021-06-08       Impact factor: 39.397
  5 in total

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