| Literature DB >> 12717433 |
Yuichi Wakabayashi1, Hisami Watanabe, Jun Inoue, Naoki Takeda, Jun Sakata, Yukio Mishima, Jiro Hitomi, Takashi Yamamoto, Masanori Utsuyama, Ohtsura Niwa, Shinichi Aizawa, Ryo Kominami.
Abstract
The gene Bcl11b, which encodes zinc finger proteins, and its paralog, Bcl11a, are associated with immune-system malignancies. We have generated Bcl11b-deficient mice that show a block at the CD4-CD8- double-negative stage of thymocyte development without any impairment in cells of B- or gammadelta T cell lineages. The Bcl11b-/- thymocytes showed unsuccessful recombination of V(beta) to D(beta) and lacked the pre-T cell receptor (TCR) complex on the cell surface, owing to the absence of Tcrb mRNA expression. In addition, we saw profound apoptosis in the thymus of neonatal Bcl11b-/- mice. These results suggest that Bcl11b is a key regulator of both differentiation and survival during thymocyte development.Entities:
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Year: 2003 PMID： 12717433 DOI： 10.1038/ni927
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606