Literature DB >> 31570377

Genetic Counseling, Personalized Medicine, and Precision Health.

Erica Ramos1.   

Abstract

Millions of individuals in the United States will have their exomes and genomes sequenced over the next 5 years as the use of genomic sequencing technologies in clinical care grows and as initiatives in personalized medicine and precision health move forward. As a result, we will see a shift away from the patient population of early adopters who pursued direct-to-consumer (DTC) testing and paid thousands of dollars to get their genomes sequenced and toward a different and more diverse set of test takers. Early data suggest that these individuals will have different motivations for pursuing genomic sequencing and will be less knowledgeable about and less confident of the benefits of genetic testing. To serve this growing population, genetic counselors must understand our future patients as well as the changing landscape of genomic testing, DTC offerings, and population sequencing initiatives.
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2020        PMID: 31570377      PMCID: PMC7461766          DOI: 10.1101/cshperspect.a036699

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN: 2157-1422            Impact factor:   5.159


  33 in total

1.  Million Veteran Program: A mega-biobank to study genetic influences on health and disease.

Authors:  John Michael Gaziano; John Concato; Mary Brophy; Louis Fiore; Saiju Pyarajan; James Breeling; Stacey Whitbourne; Jennifer Deen; Colleen Shannon; Donald Humphries; Peter Guarino; Mihaela Aslan; Daniel Anderson; Rene LaFleur; Timothy Hammond; Kendra Schaa; Jennifer Moser; Grant Huang; Sumitra Muralidhar; Ronald Przygodzki; Timothy J O'Leary
Journal:  J Clin Epidemiol       Date:  2015-10-09       Impact factor: 6.437

2.  Impact of direct-to-consumer genomic testing at long term follow-up.

Authors:  Cinnamon S Bloss; Nathan E Wineinger; Burcu F Darst; Nicholas J Schork; Eric J Topol
Journal:  J Med Genet       Date:  2013-04-04       Impact factor: 6.318

3.  Teaching genomic counseling: preparing the genetic counseling workforce for the genomic era.

Authors:  Gillian W Hooker; Kelly E Ormond; Kevin Sweet; Barbara B Biesecker
Journal:  J Genet Couns       Date:  2014-02-08       Impact factor: 2.537

4.  Disclosure of APOE genotype for risk of Alzheimer's disease.

Authors:  Robert C Green; J Scott Roberts; L Adrienne Cupples; Norman R Relkin; Peter J Whitehouse; Tamsen Brown; Susan LaRusse Eckert; Melissa Butson; A Dessa Sadovnick; Kimberly A Quaid; Clara Chen; Robert Cook-Deegan; Lindsay A Farrer
Journal:  N Engl J Med       Date:  2009-07-16       Impact factor: 91.245

Review 5.  Precision Public Health for the Era of Precision Medicine.

Authors:  Muin J Khoury; Michael F Iademarco; William T Riley
Journal:  Am J Prev Med       Date:  2015-11-04       Impact factor: 5.043

6.  A Model for Genome-First Care: Returning Secondary Genomic Findings to Participants and Their Healthcare Providers in a Large Research Cohort.

Authors:  Marci L B Schwartz; Cara Zayac McCormick; Amanda L Lazzeri; D'Andra M Lindbuchler; Miranda L G Hallquist; Kandamurugu Manickam; Adam H Buchanan; Alanna Kulchak Rahm; Monica A Giovanni; Lauren Frisbie; Carroll N Flansburg; F Daniel Davis; Amy C Sturm; Christine Nicastro; Matthew S Lebo; Heather Mason-Suares; Lisa Marie Mahanta; David J Carey; Janet L Williams; Marc S Williams; David H Ledbetter; W Andrew Faucett; Michael F Murray
Journal:  Am J Hum Genet       Date:  2018-08-09       Impact factor: 11.025

7.  Assessment of willingness to pay for expanded carrier screening among women and couples undergoing preconception carrier screening.

Authors:  Elizabeth V Clarke; Jennifer L Schneider; Frances Lynch; Tia L Kauffman; Michael C Leo; Ana G Rosales; John F Dickerson; Elizabeth Shuster; Benjamin S Wilfond; Katrina A B Goddard
Journal:  PLoS One       Date:  2018-07-18       Impact factor: 3.240

8.  Predispositional genome sequencing in healthy adults: design, participant characteristics, and early outcomes of the PeopleSeq Consortium.

Authors:  Emilie S Zoltick; Michael D Linderman; Molly A McGinniss; Erica Ramos; Madeleine P Ball; George M Church; Debra G B Leonard; Stacey Pereira; Amy L McGuire; C Thomas Caskey; Saskia C Sanderson; Eric E Schadt; Daiva E Nielsen; Scott D Crawford; Robert C Green
Journal:  Genome Med       Date:  2019-02-27       Impact factor: 11.117

9.  Dealing with the unexpected: consumer responses to direct-access BRCA mutation testing.

Authors:  Uta Francke; Cheri Dijamco; Amy K Kiefer; Nicholas Eriksson; Bianca Moiseff; Joyce Y Tung; Joanna L Mountain
Journal:  PeerJ       Date:  2013-02-12       Impact factor: 2.984

10.  Cystic fibrosis population carrier screening: 2004 revision of American College of Medical Genetics mutation panel.

Authors:  Michael S Watson; Garry R Cutting; Robert J Desnick; Deborah A Driscoll; Katherine Klinger; Michael Mennuti; Glenn E Palomaki; Bradley W Popovich; Victoria M Pratt; Elizabeth M Rohlfs; Charles M Strom; C Sue Richards; David R Witt; Wayne W Grody
Journal:  Genet Med       Date:  2004 Sep-Oct       Impact factor: 8.822

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  1 in total

Review 1.  Genetic Counseling and the Central Tenets of Practice.

Authors:  Barbara Biesecker
Journal:  Cold Spring Harb Perspect Med       Date:  2020-03-02       Impact factor: 6.915

  1 in total

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