Griffith A Bell1, Neil Perkins1, Germaine M Buck Louis1,2, Kurunthachalam Kannan3, Erin M Bell4, Chongjing Gao3, Edwina H Yeung1. 1. From the Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. 2. Dean's Office, College of Health and Human Services, George Mason University, Fairfax, VA. 3. Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY. 4. Department of Environmental Health Services, University at Albany, State University of New York, Albany, NY.
Abstract
BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs) may be associated with obesogenic effects in offspring. Our study is the first to investigate associations between concentrations of POPs from newborn dried blood spots (DBS) and birth characteristics. METHODS: Concentrations of 10 polychlorinated biphenyl congeners (PCBs), polybrominated diphenyl ether-47 (PBDE-47), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were measured from DBSs collected at birth from 2,065 singleton infants. DBS samples were pooled in groups of five and assayed together to reach limits of detection. Differences in risk of large for gestational age (LGA, defined as >90th percentile of birth weight for sex and gestational age), small for gestational age (SGA, <10th), and preterm birth (gestational age <37 weeks) were estimated using logistic regression per unit (ng/ml) increase in concentration of each chemical, adjusting for individual-level covariates, including maternal age, race/ethnicity, prepregnancy BMI, education, parity, smoking, and infant sex while assuming a gamma distribution and using multiple imputation to account for pools. RESULTS: There were 215 (11.3%) singletons born LGA, 158 (7.5%) born SGA, and 157 (7.6%) born preterm. Higher concentrations of POPs were positively associated with slightly higher risk of LGA and higher birth weight. CONCLUSIONS: Relationships between POPs measured in newborn DBS and birth size were mixed. Pooled analysis methods using DBS could address challenges in limits of detection and costs for population-based research.
BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs) may be associated with obesogenic effects in offspring. Our study is the first to investigate associations between concentrations of POPs from newborn dried blood spots (DBS) and birth characteristics. METHODS: Concentrations of 10 polychlorinated biphenyl congeners (PCBs), polybrominated diphenyl ether-47 (PBDE-47), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were measured from DBSs collected at birth from 2,065 singleton infants. DBS samples were pooled in groups of five and assayed together to reach limits of detection. Differences in risk of large for gestational age (LGA, defined as >90th percentile of birth weight for sex and gestational age), small for gestational age (SGA, <10th), and preterm birth (gestational age <37 weeks) were estimated using logistic regression per unit (ng/ml) increase in concentration of each chemical, adjusting for individual-level covariates, including maternal age, race/ethnicity, prepregnancy BMI, education, parity, smoking, and infant sex while assuming a gamma distribution and using multiple imputation to account for pools. RESULTS: There were 215 (11.3%) singletons born LGA, 158 (7.5%) born SGA, and 157 (7.6%) born preterm. Higher concentrations of POPs were positively associated with slightly higher risk of LGA and higher birth weight. CONCLUSIONS: Relationships between POPs measured in newborn DBS and birth size were mixed. Pooled analysis methods using DBS could address challenges in limits of detection and costs for population-based research.
Authors: D Mullerova; M Pesta; J Dvorakova; M Cedikova; V Kulda; P Dvorak; V Bouchalová; M Kralickova; V Babuska; J Kuncova; J Langmajerova; L Muller Journal: Physiol Res Date: 2017-04-12 Impact factor: 1.881
Authors: Maribel Casas; Mark Nieuwenhuijsen; David Martínez; Ferran Ballester; Xavier Basagaña; Mikel Basterrechea; Leda Chatzi; Cécile Chevrier; Merete Eggesbø; Mariana F Fernandez; Eva Govarts; Mònica Guxens; Joan O Grimalt; Irva Hertz-Picciotto; Nina Iszatt; Monika Kasper-Sonnenberg; Hannu Kiviranta; Manolis Kogevinas; Lubica Palkovicova; Ulrich Ranft; Greet Schoeters; Evridiki Patelarou; Maria Skaalum Petersen; Maties Torrent; Tomas Trnovec; Damaskini Valvi; Gunnar Vase Toft; Pál Weihe; Nynke Weisglas-Kuperus; Michael Wilhelm; Jürgen Wittsiepe; Martine Vrijheid; Jens Peter Bonde Journal: Environ Int Date: 2014-10-11 Impact factor: 9.621
Authors: Jerrold J Heindel; Bruce Blumberg; Mathew Cave; Ronit Machtinger; Alberto Mantovani; Michelle A Mendez; Angel Nadal; Paola Palanza; Giancarlo Panzica; Robert Sargis; Laura N Vandenberg; Frederick Vom Saal Journal: Reprod Toxicol Date: 2016-10-17 Impact factor: 3.143
Authors: Michael S Bloom; Germaine M Buck Louis; Enrique F Schisterman; Aiyi Liu; Paul J Kostyniak Journal: Environ Health Perspect Date: 2007-09 Impact factor: 9.031
Authors: Tyler A Jacobson; Jasdeep S Kler; Yeunook Bae; Jiexi Chen; Daniel T Ladror; Ramsunder Iyer; Denise A Nunes; Nathan D Montgomery; Joachim D Pleil; William E Funk Journal: J Expo Sci Environ Epidemiol Date: 2022-08-13 Impact factor: 6.371