A de la Torre-Luque1,2,3, J de la Fuente1,2,3, A Sanchez-Niubo1,4, F F Caballero5,6, M Prina7, G Muniz-Terrera8, J M Haro1,4, J L Ayuso-Mateos1,2,3. 1. Centre for Biomedical Research in Mental Health (CIBERSAM), Madrid, Spain. 2. Department of Psychiatry, Universidad Autónoma de Madrid, Madrid, Spain. 3. Department of Psychiatry, Instituto de Investigación Sanitaria Princesa (IIS Princesa), Madrid, Spain. 4. Parc Sanitari Sant Joan de Déu, Fundació Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain. 5. Department of Preventive Medicine, Public Health, and Microbiology, Universidad Autónoma de Madrid, Madrid, Spain. 6. Centre for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain. 7. Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. 8. Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
Abstract
AIMS: To study the temporal dynamics of depression symptom episodes in old-age and the related influence of risk factors. METHODS: Data from 41 362 old adults (54.61% women; mean age = 75.30, SD = 6.20) from the Ageing Trajectories of Health - Longitudinal Opportunities and Synergies (ATHLOS) project were used. Depressive symptoms were followed over an 18-year period. A multi-state model, comprising three statuses (no depression, new clinically relevant episode of symptoms and episode persistence), was fitted. Multinomial regression was used to study the role of risk factors in status transition. RESULTS: Almost 85% of participants showed no depression, but prevalence became lower over time (B = -0.25, P < 0.001). New episode point prevalence was over 5.30% with a significant probability of moving to persistence status (transition probability = 0.27). Episode persistence became evident in 9.86% of episode status transitions, with increasing rate over time (B = 0.54, P < 0.01). Loneliness was proven to be the strongest predictor of episode emergence (OR = 17.76) and persistence (OR = 5.93). CONCLUSIONS: The course of depression tends to become chronic and unremitting in old-age. This study may help to plan interventions to tackle symptom escalation and risk factor influence.
AIMS: To study the temporal dynamics of depression symptom episodes in old-age and the related influence of risk factors. METHODS: Data from 41 362 old adults (54.61% women; mean age = 75.30, SD = 6.20) from the Ageing Trajectories of Health - Longitudinal Opportunities and Synergies (ATHLOS) project were used. Depressive symptoms were followed over an 18-year period. A multi-state model, comprising three statuses (no depression, new clinically relevant episode of symptoms and episode persistence), was fitted. Multinomial regression was used to study the role of risk factors in status transition. RESULTS: Almost 85% of participants showed no depression, but prevalence became lower over time (B = -0.25, P < 0.001). New episode point prevalence was over 5.30% with a significant probability of moving to persistence status (transition probability = 0.27). Episode persistence became evident in 9.86% of episode status transitions, with increasing rate over time (B = 0.54, P < 0.01). Loneliness was proven to be the strongest predictor of episode emergence (OR = 17.76) and persistence (OR = 5.93). CONCLUSIONS: The course of depression tends to become chronic and unremitting in old-age. This study may help to plan interventions to tackle symptom escalation and risk factor influence.
Authors: Malcolm P Forbes; Adrienne O'Neil; Melissa Lane; Bruno Agustini; Nick Myles; Michael Berk Journal: Drugs Aging Date: 2021-04-29 Impact factor: 3.923
Authors: Petros Barmpas; Sotiris Tasoulis; Aristidis G Vrahatis; Spiros V Georgakopoulos; Panagiotis Anagnostou; Matthew Prina; José Luis Ayuso-Mateos; Jerome Bickenbach; Ivet Bayes; Martin Bobak; Francisco Félix Caballero; Somnath Chatterji; Laia Egea-Cortés; Esther García-Esquinas; Matilde Leonardi; Seppo Koskinen; Ilona Koupil; Andrzej Paja K; Martin Prince; Warren Sanderson; Sergei Scherbov; Abdonas Tamosiunas; Aleksander Galas; Josep Maria Haro; Albert Sanchez-Niubo; Vassilis P Plagianakos; Demosthenes Panagiotakos Journal: Health Inf Sci Syst Date: 2022-04-18