Specialized source-detector separations in near-infrared reflectance spectroscopy platform enable effective separation of diffusion and absorption for glucose sensing.

We present an approach for accurate glucose sensing in turbid media using a spectrally resolved reflectance setup. Our proposed reflectance setup uses specialized source-detector separations (SDSs) to enable an effective separation of diffusion and absorption signals. Additionally, we adjust the selected SDSs to their optimal values to acquire maximum sensitivity to glucose in the two signals. The separation can help to enhance the sensitivity to glucose both for the diffusion and absorption signals, as they always suppress each other by causing opposite effects on the reflected diffuse light intensity. Monte Carlo simulations and experiments for glucose sensing are used to test the method. The acquired optimal SDSs could provide a reference for noninvasive blood glucose sensing.