Huseyin Mayali1, Muhammed Altinisik2, Secil Sencan3, Timur Pirildar1, Emin Kurt1. 1. Ophthalmology Department, Medical School, Manisa Celal Bayar University, Manisa, Turkey. 2. Ophthalmology Department, Medical School, Manisa Celal Bayar University, Manisa, Turkey. dr.maltinisik@gmail.com. 3. Ophthalmology Department, Tinaztepe Hospital, Izmir, Turkey.
Abstract
PURPOSE: To conduct a multimodal ophthalmic evaluation of systemic sclerosis (SSc) in patients using ocular response analyzer (ORA), Pentacam, and specular microscopy (SM). METHODS: Thirty-one SSc patients and a group of age- and sex-matched controls were enrolled in this cross-sectional study. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with ORA. Anterior chamber depth (ACD), central corneal thickness (CCT), and corneal volume (CV) measurements were obtained using Pentacam. Corneal endothelial cell density (ECD) and CCT were evaluated by SM. RESULTS: SSc patients had significantly lower CH, ACD, and ECD values compared to the control group (p = 0.018; < 0.001; < 0.001, respectively). There was no significant difference regarding CRF, IOP, CV, or CCT measurements acquired by Pentacam and SM. Regarding CCT, SM and Pentacam showed relatively better agreement in SSc patients. CONCLUSIONS: Multimodal imaging can provide more comprehensive and useful information regarding the ocular involvement of systemic diseases. The multimodal evaluation in our study demonstrated that the pathologic effects of SSc may manifest as reductions in ACD, corneal elasticity, and ECD before there are any detectable changes in corneal thickness or IOP.
PURPOSE: To conduct a multimodal ophthalmic evaluation of systemic sclerosis (SSc) in patients using ocular response analyzer (ORA), Pentacam, and specular microscopy (SM). METHODS: Thirty-one SScpatients and a group of age- and sex-matched controls were enrolled in this cross-sectional study. Corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg) were measured with ORA. Anterior chamber depth (ACD), central corneal thickness (CCT), and corneal volume (CV) measurements were obtained using Pentacam. Corneal endothelial cell density (ECD) and CCT were evaluated by SM. RESULTS:SScpatients had significantly lower CH, ACD, and ECD values compared to the control group (p = 0.018; < 0.001; < 0.001, respectively). There was no significant difference regarding CRF, IOP, CV, or CCT measurements acquired by Pentacam and SM. Regarding CCT, SM and Pentacam showed relatively better agreement in SScpatients. CONCLUSIONS: Multimodal imaging can provide more comprehensive and useful information regarding the ocular involvement of systemic diseases. The multimodal evaluation in our study demonstrated that the pathologic effects of SSc may manifest as reductions in ACD, corneal elasticity, and ECD before there are any detectable changes in corneal thickness or IOP.
Authors: Patricia Martin; Walcy R Teodoro; Ana Paula P Velosa; Jymenez de Morais; Solange Carrasco; Romy B Christmann; Cláudia Goldenstein-Schainberg; Edwin R Parra; Maria Lúcia Katayama; Mirian N Sotto; Vera L Capelozzi; Natalino H Yoshinari Journal: Autoimmun Rev Date: 2012-03-02 Impact factor: 9.754
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