Olga Therese Ousdal1, Miklos Argyelan2, Katherine L Narr3, Christopher Abbott4, Benjamin Wade3, Mathieu Vandenbulcke5, Mikel Urretavizcaya6, Indira Tendolkar7, Akihiro Takamiya8, Max L Stek9, Carles Soriano-Mas10, Ronny Redlich11, Olaf B Paulson12, Mardien L Oudega9, Nils Opel13, Pia Nordanskog14, Taishiro Kishimoto15, Robin Kampe14, Anders Jorgensen16, Lars G Hanson17, J Paul Hamilton14, Randall Espinoza3, Louise Emsell5, Philip van Eijndhoven18, Annemieke Dols9, Udo Dannlowski11, Narcis Cardoner19, Filip Bouckaert5, Amit Anand20, Hauke Bartsch21, Ute Kessler22, Ketil J Oedegaard22, Anders M Dale23, Leif Oltedal24. 1. Department of Radiology, Haukeland University Hospital, Bergen, Norway. Electronic address: olgatherese.ousdal@gmail.com. 2. Center for Psychiatric Neuroscience at the Feinstein Institute for Medical Research, New York, New York. 3. Departments of Neurology, Psychiatry, and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles. 4. Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico. 5. Department of Geriatric Psychiatry, University Psychiatric Center Katholieke Universiteit Leuven, Katholieke Universiteit Leuven, Leuven, Belgium. 6. Department of Psychiatry, Bellvitge University Hospital-Bellvitge Biomedical Research Institute; Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain. 7. Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Donders Institute for Brain Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands; Faculty of Medicine and Landschaftsverband Rheinland Clinic for Psychiatry and Psychotherapy, University of Duisburg-Essen, Duisburg-Essen, Germany. 8. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan; Center for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, Japan. 9. Geestelijke GezondheidsZorg inGeest Specialized Mental Health Care, Amsterdam, The Netherlands; Amsterdam University Medical Center, Vrije Universiteit Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands. 10. Department of Psychiatry, Bellvitge University Hospital-Bellvitge Biomedical Research Institute; Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain. 11. Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany. 12. Neurobiology Research Unit, Department of Neurology, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 13. Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany; Interdisciplinary Centre for Clinical Research (IZKF), University of Muenster, Muenster, Germany. 14. Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. 15. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. 16. Psychiatric Center Copenhagen (Rigshospitalet), Mental Health Services of the Capital Region of Denmark, Copenhagen, Denmark. 17. Center for Magnetic Resonance, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark; Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark. 18. Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands; Donders Institute for Brain Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, The Netherlands. 19. Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain; Department of Mental Health, University Hospital Parc Taulí-I3PT, Sabadell, Spain. 20. Cleveland Clinic, Center for Behavioral Health, Cleveland, Ohio. 21. Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, California; Department of Radiology, University of California, San Diego, La Jolla, California. 22. Norwegian Centre for Mental Disorders Research, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway. 23. Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, California; Department of Radiology, University of California, San Diego, La Jolla, California; Department of Neurosciences, University of California, San Diego, La Jolla, California. 24. Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Abstract
BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean ± SD of 1.04 ± 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 ± 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation ρ = -.44, p < .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.
BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean ± SD of 1.04 ± 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 ± 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation ρ = -.44, p < .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.
Authors: Miklos Argyelan; Leif Oltedal; Zhi-De Deng; Benjamin Wade; Marom Bikson; Andrea Joanlanne; Sohag Sanghani; Hauke Bartsch; Marta Cano; Anders M Dale; Udo Dannlowski; Annemiek Dols; Verena Enneking; Randall Espinoza; Ute Kessler; Katherine L Narr; Ketil J Oedegaard; Mardien L Oudega; Ronny Redlich; Max L Stek; Akihiro Takamiya; Louise Emsell; Filip Bouckaert; Pascal Sienaert; Jesus Pujol; Indira Tendolkar; Philip van Eijndhoven; Georgios Petrides; Anil K Malhotra; Christopher Abbott Journal: Elife Date: 2019-10-23 Impact factor: 8.140
Authors: M G A Van Cauwenberge; F Bouckaert; K Vansteelandt; C Adamson; F L De Winter; P Sienaert; J Van den Stock; A Dols; D Rhebergen; M L Stek; L Emsell; M Vandenbulcke Journal: Transl Psychiatry Date: 2021-04-01 Impact factor: 6.222
Authors: Olga Therese Ousdal; Giulio E Brancati; Ute Kessler; Vera Erchinger; Anders M Dale; Christopher Abbott; Leif Oltedal Journal: Biol Psychiatry Date: 2021-05-31 Impact factor: 13.382
Authors: Nils Opel; Katherine L. Narr; Christopher Abbott; Miklos Argyelan; Randall Espinoza; Louise Emsell; Filip Bouckaert; Pascal Sienaert; Mathieu Vandenbulcke; Pia Nordanskog; Jonathan Repple; Erhan Kavakbasi; Martin B. Jorgensen; Olaf B. Paulson; Lars G. Hanson; Annemieke Dols; Eric van Exel; Mardien L. Oudega; Akihiro Takamiya; Taishiro Kishimoto; Olga Therese Ousdal; Jan Haavik; Åsa Hammar; Ketil Joachim Oedegaard; Ute Kessler; Hauke Bartsch; Anders M. Dale; Bernhard T. Baune; Udo Dannlowski; Leif Oltedal; Ronny Redlich Journal: J Psychiatry Neurosci Date: 2021-07-05 Impact factor: 6.186