INTRODUCTION: Carbapenemase-producing <i>Enterobacteriaceae</i> have spread rapidly through the countries and continents to become a global concern. One of the main reservoirs of NDM-1 positive strains from the <i>Enterobacteriaceae</i> family is the Indian subcontinent (Bangladesh, Pakistan, India). MATERIAL AND METHODS: During June 2017 - June 2018, rectal swab samples were collected routinely in all patients returning to Poland from South and South-East Asia. During molecular examinations gene <i>bla</i><sub>NDM-1</sub> encoding NDM-1 carbapenemase was detected. RESULTS: 31 patients were examined after returning to Poland from a trip to South and South-East Asia. The presence of New Delhi Metallo-β-lactamase-1 producing<i> Escherichia</i> <i>coli</i> and <i>Klebsiella pneumoniae</i> was confirmed in three patients (9.7%) returning to Poland from travels to India. All the positive patients were hospitalized during the trip in a New Delhi hospital. CONCLUSIONS: Digestive tract carriage of NDM in a group of Polish travelers is a significant health and epidemiological problem. The study confirms the necessity for screening for carbapenemase-producing <i>Enterobacteriaceae</i> (CPE), particularly among travellers. Rectal swabs should be collected in every case of patients returning from international trips, and the possibility of environment-associated infections should be emphasized.
INTRODUCTION: Carbapenemase-producing <i>Enterobacteriaceae</i> have spread rapidly through the countries and continents to become a global concern. One of the main reservoirs of NDM-1 positive strains from the <i>Enterobacteriaceae</i> family is the Indian subcontinent (Bangladesh, Pakistan, India). MATERIAL AND METHODS: During June 2017 - June 2018, rectal swab samples were collected routinely in all patients returning to Poland from South and South-East Asia. During molecular examinations gene <i>bla</i><sub>NDM-1</sub> encoding NDM-1 carbapenemase was detected. RESULTS: 31 patients were examined after returning to Poland from a trip to South and South-East Asia. The presence of New Delhi Metallo-β-lactamase-1 producing<i> Escherichia</i> <i>coli</i> and <i>Klebsiella pneumoniae</i> was confirmed in three patients (9.7%) returning to Poland from travels to India. All the positive patients were hospitalized during the trip in a New Delhi hospital. CONCLUSIONS: Digestive tract carriage of NDM in a group of Polish travelers is a significant health and epidemiological problem. The study confirms the necessity for screening for carbapenemase-producing <i>Enterobacteriaceae</i> (CPE), particularly among travellers. Rectal swabs should be collected in every case of patients returning from international trips, and the possibility of environment-associated infections should be emphasized.
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Keywords:
CPE; NDM; New Delhi Metallo-β-lactamase; carbapenemase; carbapenems; travelers’ diarrhea