Qiuyun Xu1, Elmira Jalilian2, Joseph W Fakhoury3, Rayyan Manwar1, Bozena Michniak-Kohn4, Kenneth B Elkin3, Kamran Avanaki1. 1. Department of Biomedical Engineering, Wayne State University, Detroit, MI, USA. 2. UCL Institute of Ophthalmology, University College London, London, UK. 3. Wayne State University School of Medicine, Detroit, MI, USA. 4. Center for Dermal Research (CDR) & Laboratory for Drug Delivery (LDD), Rutgers-The State University of New Jersey, New Brunswick, NJ, USA.
Abstract
BACKGROUND: Optical coherence tomography (OCT) is a promising imaging modality for skin cancer diagnosis. However, this capability has been hindered by the low contrast between normal and neoplastic tissue. To overcome this limitation, gold nanoparticles have been used to enhance the contrast in OCT images and are topically administered to reduce the risk of systematic side effects associated with intravenous injection. To ensure efficient penetration and distribution of the nanoparticles, an enhanced delivery strategy is required. In this porcine study, we assessed two delivery methods: (a) using dimethyl sulfoxide (DMSO) and (b) via sonophoresis. MATERIALS AND METHODS: The gold nanoparticles were topically applied on pig skin before evaluating DMSO and sonophoresis as penetration enhancers in topical administration. The OCT images were taken from the same locations to monitor signal change. CONCLUSION: The combination of DMSO and sonophoresis is an effective method to enhance the penetration and diffusion rate of nanoparticles during topical administration. SIGNIFICANCE: Topical administration of nanoparticles is advantageous in dermatological applications. Nevertheless, efficient topical delivery remains a challenge. DMSO and sonophoresis can be used as two effective approaches to enhance topical delivery of nanoparticles.
BACKGROUND: Optical coherence tomography (OCT) is a promising imaging modality for skin cancer diagnosis. However, this capability has been hindered by the low contrast between normal and neoplastic tissue. To overcome this limitation, gold nanoparticles have been used to enhance the contrast in OCT images and are topically administered to reduce the risk of systematic side effects associated with intravenous injection. To ensure efficient penetration and distribution of the nanoparticles, an enhanced delivery strategy is required. In this porcine study, we assessed two delivery methods: (a) using dimethyl sulfoxide (DMSO) and (b) via sonophoresis. MATERIALS AND METHODS: The gold nanoparticles were topically applied on pig skin before evaluating DMSO and sonophoresis as penetration enhancers in topical administration. The OCT images were taken from the same locations to monitor signal change. CONCLUSION: The combination of DMSO and sonophoresis is an effective method to enhance the penetration and diffusion rate of nanoparticles during topical administration. SIGNIFICANCE: Topical administration of nanoparticles is advantageous in dermatological applications. Nevertheless, efficient topical delivery remains a challenge. DMSO and sonophoresis can be used as two effective approaches to enhance topical delivery of nanoparticles.
Authors: Tin Man Lee; Amy L Oldenburg; Shoeb Sitafalwalla; Daniel L Marks; Wei Luo; Farah Jean-Jacques Toublan; Kenneth S Suslick; Stephen A Boppart Journal: Opt Lett Date: 2003-09-01 Impact factor: 3.776
Authors: Ralf P Friedrich; Mona Kappes; Iwona Cicha; Rainer Tietze; Christian Braun; Regine Schneider-Stock; Roland Nagy; Christoph Alexiou; Christina Janko Journal: Int J Nanomedicine Date: 2022-05-13