Hugo Câmara-Costa1,2, Marion Opatowski3, Leila Francillette4, Hanna Toure5, Dominique Brugel5,6, Anne Laurent-Vannier5, Philippe Meyer7,8, Laurence Watier4, Georges Dellatolas9, Mathilde Chevignard10,5,6. 1. Université Paris-Saclay, Université Paris-SUD, UVSQ, CESP, INSERM, 97, Boulevard de Port Royal, 75014, Paris, France. hugocamaracosta@gmail.com. 2. Laboratoire d'Imagerie Biomédicale, LIB, Sorbonne Université, Paris, France. hugocamaracosta@gmail.com. 3. Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), INSERM, UVSQ, Institut Pasteur, Université Paris-Saclay, Paris, France. 4. Sorbonne Université, Paris, France. 5. Rehabilitation Department for Children with Acquired Neurological Injury, Outreach Team for Children and Adolescents With Acquired Brain Injury, Hôpitaux de Saint Maurice, Saint Maurice, France. 6. GRC 24, HaMCRe, Sorbonne Université, Paris, France. 7. Paediatric Anesthesiology Department, Hôpital Necker Enfants Malades, Paris, France. 8. Faculté de Médecine René Descartes, Paris 5, Paris, France. 9. Université Paris-Saclay, Université Paris-SUD, UVSQ, CESP, INSERM, 97, Boulevard de Port Royal, 75014, Paris, France. 10. Laboratoire d'Imagerie Biomédicale, LIB, Sorbonne Université, Paris, France.
Abstract
PURPOSE: To investigate self- and parent-reported Health-Related Quality-of-Life (HRQoL) and their associations after severe childhood traumatic brain injury (TBI) in the Traumatisme Grave de l'Enfant (TGE) cohort. METHODS: Self- (n = 34) and/or parent-reports (n = 25) of HRQoL were collected for 38 participants (age 7-22 years) 7 years after severe childhood TBI. The collected data included sociodemographic characteristics, injury severity indices, and overall disability and functional outcome at 3-months, 1- and 2-years post-injury. At 7-years post-injury, data were collected in the TBI group and in a control group (n = 33): overall disability (Glasgow Outcome Scale Extended), intellectual ability (IQ), and questionnaires assessing HRQoL (Pediatric Quality of Life Inventory), executive functions (Behavior Rating Inventory of Executive Functions), behavior (Child Behavior Checklist), fatigue (Multidimensional Fatigue Scale) and participation (Child and Adolescent Scale of Participation). RESULTS: Parent- and self-reports of HRQoL were significantly lower in the TBI group than in the control group. Parent-rated HRQoL was not associated with objectively assessed factors, whereas self-reported HRQoL was associated with gender (worse in females) and initial functional outcome. All questionnaire scores completed by the same informant (self or parent) were strongly inter-correlated. CONCLUSIONS: Reported HRQoL 7-years after severe childhood TBI is low compared to controls, weakly or not-related to objective factors, such as injury severity indices, clinically assessed functional outcomes, or IQ, but strongly related to reports by the same informant of executive deficits, behavior problems, fatigue, and participation.
PURPOSE: To investigate self- and parent-reported Health-Related Quality-of-Life (HRQoL) and their associations after severe childhood traumatic brain injury (TBI) in the Traumatisme Grave de l'Enfant (TGE) cohort. METHODS: Self- (n = 34) and/or parent-reports (n = 25) of HRQoL were collected for 38 participants (age 7-22 years) 7 years after severe childhood TBI. The collected data included sociodemographic characteristics, injury severity indices, and overall disability and functional outcome at 3-months, 1- and 2-years post-injury. At 7-years post-injury, data were collected in the TBI group and in a control group (n = 33): overall disability (Glasgow Outcome Scale Extended), intellectual ability (IQ), and questionnaires assessing HRQoL (Pediatric Quality of Life Inventory), executive functions (Behavior Rating Inventory of Executive Functions), behavior (Child Behavior Checklist), fatigue (Multidimensional Fatigue Scale) and participation (Child and Adolescent Scale of Participation). RESULTS: Parent- and self-reports of HRQoL were significantly lower in the TBI group than in the control group. Parent-rated HRQoL was not associated with objectively assessed factors, whereas self-reported HRQoL was associated with gender (worse in females) and initial functional outcome. All questionnaire scores completed by the same informant (self or parent) were strongly inter-correlated. CONCLUSIONS: Reported HRQoL 7-years after severe childhood TBI is low compared to controls, weakly or not-related to objective factors, such as injury severity indices, clinically assessed functional outcomes, or IQ, but strongly related to reports by the same informant of executive deficits, behavior problems, fatigue, and participation.
Entities:
Keywords:
Adolescent; Child; Health-related Quality of Life; Prospective cohort study; Severe traumatic brain injury
Authors: Terry Stancin; Dennis Drotar; H Gerry Taylor; Keith Owen Yeates; Shari L Wade; Nori Mercuri Minich Journal: Pediatrics Date: 2002-02 Impact factor: 7.124
Authors: Colin Kennedy; Kim Bull; Mathilde Chevignard; David Culliford; Helmuth G Dörr; François Doz; Rolf-Dieter Kortmann; Birgitta Lannering; Maura Massimino; Aurora Navajas Gutiérrez; Stefan Rutkowski; Helen A Spoudeas; Gabriele Calaminus Journal: Int J Radiat Oncol Biol Phys Date: 2013-11-13 Impact factor: 7.038