Waleed Kurtom1, Benjamin Courchia2,3, Alyssa Pensirikul2,4, Ilene Sosenko2,3, Teresa Del-Moral2,3. 1. Division of Neonatology, Children's National Medical Center, Washington, District of Columbia, Washington, DC, USA. wkurtom@childrensnational.org. 2. Department of Pediatrics, University of Miami Miller School of Medicine-Jackson Memorial Hospital, Washington, FL, USA. 3. Division of Neonatology, Miami, FL, USA. 4. Division of Pediatric Neurology, University of Miami Miller School of Medicine-Jackson Memorial Hospital, Miami, FL, USA.
Abstract
OBJECTIVE: The aim of this study was to evaluate the effectiveness of monotherapy with levetiracetam (LEV) in achieving seizure cessation in a retrospective cohort of extreme preterm infants with seizures. STUDY DESIGN: Charts of infants with a diagnosis of neonatal seizures admitted to the NICU between 2013 and 2017 were reviewed. Seizures were diagnosed using continuous video electroencephalography. All infants were initially started on LEV and reached a dose of 80 mg/kg/day. Other ASMs were added to LEV if seizures continued after 2 days. Data on additional clinical variables were collected for each infant. RESULT: Sixty-one infants born <28 weeks of gestation met inclusion criteria. Seventy-four percent of patients did not respond to LEV monotherapy and required additional medications. CONCLUSIONS: LEV monotherapy stopped seizures in only a small portion of cases.
OBJECTIVE: The aim of this study was to evaluate the effectiveness of monotherapy with levetiracetam (LEV) in achieving seizure cessation in a retrospective cohort of extreme preterm infants with seizures. STUDY DESIGN: Charts of infants with a diagnosis of neonatal seizures admitted to the NICU between 2013 and 2017 were reviewed. Seizures were diagnosed using continuous video electroencephalography. All infants were initially started on LEV and reached a dose of 80 mg/kg/day. Other ASMs were added to LEV if seizures continued after 2 days. Data on additional clinical variables were collected for each infant. RESULT: Sixty-one infants born <28 weeks of gestation met inclusion criteria. Seventy-four percent of patients did not respond to LEV monotherapy and required additional medications. CONCLUSIONS: LEV monotherapy stopped seizures in only a small portion of cases.
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