Xiaowei Jiang1, Shinan Fu2, Zhiyang Yin2, Jiahui Kang2, Xinrui Wang2, Yifang Zhou3, Shengnan Wei4, Feng Wu2, Lingtao Kong2, Fei Wang5, Yanqing Tang6. 1. Brain Function Research Section, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China; Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China; Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China. 2. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China. 3. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China; Department of Geriatric Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China. 4. Brain Function Research Section, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China; Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China. 5. Brain Function Research Section, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China; Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China; Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China. Electronic address: fei.wang@cmu.edu.cn. 6. Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China; Department of Geriatric Medicine, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, China. Electronic address: tangyanqing@cmu.edu.cn.
Abstract
BACKGROUND: It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases. METHODS: FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BD patients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups. RESULTS: Compared to HC, FE-BD patients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions. LIMITATIONS: The potential effects of medicine, age, course of disease and handedness on results could not be ignored. CONCLUSIONS: Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders.
BACKGROUND: It is difficult to distinguish bipolar disorder (BD) from major depressive disorder (MDD), especially with the initial depressive episode. In this study, we compared neural activities of BD and MDD patients during the first-episode (FE) to investigate common and distinct neural activities and further explore predictive indicators in the two diseases. METHODS: FE-MDD patients were performed resting state functional magnetic resonance imaging and followed up after scanning. After follow-up, FE-MDD patients were regrouped into FE-BD and FE-MDD patients. The study included 24 FE-BDpatients, 28 FE-MDD patients, and 30 age- and sex-matched healthy controls (HC) to investigate neural activities with regional homogeneity (ReHo) analysis among the 3 groups. RESULTS: Compared to HC, FE-BDpatients displayed significantly higher ReHo values in the superior frontal gyrus, the medial superior frontal gyrus within right-side cerebral hemisphere than FE-MDD patients and HC. Compared to HC, FE-BD and FE-MDD patients displayed significant decreased ReHo values in the paracentral lobule, the precuneus and the median cingulate and paracingulate gyrus within bilateral cerebral hemisphere, and the postcentral gyrus and the precentral gyrus within the right-side. FE-BD displayed significant lower ReHo values than FE-MDD patients in these regions. LIMITATIONS: The potential effects of medicine, age, course of disease and handedness on results could not be ignored. CONCLUSIONS: Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of affective disorders.
Authors: Sabina Rai; Kristi R Griffiths; Isabella A Breukelaar; Ana R Barreiros; Wenting Chen; Philip Boyce; Philip Hazell; Sheryl L Foster; Gin S Malhi; Anthony W F Harris; Mayuresh S Korgaonkar Journal: Transl Psychiatry Date: 2021-10-23 Impact factor: 6.222
Authors: Sungkean Kim; Ji Hyun Baek; Se-Hoon Shim; Young Joon Kwon; Hwa Young Lee; Jae Hyun Yoo; Ji Sun Kim Journal: Sci Rep Date: 2022-04-08 Impact factor: 4.379