| Literature DB >> 31538643 |
Sylvie Behillil1, Faten May2,3, Slim Fourati4, Charles-Edouard Luyt5, Thomas Chicheportiche5, Romain Sonneville6, Yacine Tandjaoui-Lambiotte7, Damien Roux8, Laurent Guérin9, Julien Mayaux10, Eric Maury11, Alexis Ferré12, Jean-François Georger13, Guillaume Voiriot14, Vincent Enouf1, Sylvie van der Werf1, Armand Mekontso Dessap2,3, Nicolas de Prost2,3.
Abstract
In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day 28 mortality than others (80% vs 12%; P = .011).Entities:
Keywords: H1N1 subtype; adult; influenza A virus; oseltamivir; pneumonia; respiratory distress syndrome; viral
Year: 2020 PMID: 31538643 DOI: 10.1093/cid/ciz904
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079