Fergus W Gardiner1,2,3,4, Ruth McCuaig2, Chris Arthur5, Thomas Carins5, Adam Morton6, Josephine Laurie6, Teresa Neeman4, Boon Lim2,4, Michael J Peek2,4. 1. The Calvary Public Hospital Bruce, Australia. 2. The Canberra Hospital, Canberra, Australia. 3. The Royal Flying Doctor Service, Barton, Australia. 4. The Australian National University, Canberra, Australia. 5. The Gold Coast University Health, Gold Coast, Australia. 6. Mater Health Services Public Hospital, Brisbane, Australia.
Abstract
BACKGROUND: To determine the prevalence and outcomes of intrahepatic cholestasis of pregnancy. METHODS: A review comparing intrahepatic cholestasis of pregnancy pregnancies to all other pregnancies in three tertiary care Australian hospitals over a 36-month period. RESULTS: There were 43,876 pregnancies. The prevalence of intrahepatic cholestasis of pregnancies (n = 319) was 0.7%. There were differences between intrahepatic cholestasis of pregnancy and non-intrahepatic cholestasis of pregnancy mothers including higher prevalence of South Asian (22.6% versus 3.1%, p < 0.001), Indigenous Australian (3.8% versus 1.8%, p < 0.05), and Asian ethnicity (8.4% versus 5.7%, p < 0.05), mothers with a body mass index >35 kg/m2 (10.6% versus 5.5%, p < 0.001), those with diabetes mellitus (25.7% versus 9.8%, p < 0.001), and those with twin births (8.7% versus 2.2%, p < 0.001). The primary clinical outcomes of intrahepatic cholestasis of pregnancy included a median gestational age at delivery of 36.4 (SE 0.09) weeks compared to 38.6 (SE 0.01) weeks (p < 0.001), a lower birth weight (3.12 (SE 0.03) versus 3.31 kg (SE 0.03), p < 0.001), and an increase in special care nursery admissions (44.5% versus 15.3%, p < 0.001). CONCLUSION: Treated intrahepatic cholestasis of pregnancy in the population described here had similar mortality outcomes although increased special care nursery admission as compared to the general population.
BACKGROUND: To determine the prevalence and outcomes of intrahepatic cholestasis of pregnancy. METHODS: A review comparing intrahepatic cholestasis of pregnancy pregnancies to all other pregnancies in three tertiary care Australian hospitals over a 36-month period. RESULTS: There were 43,876 pregnancies. The prevalence of intrahepatic cholestasis of pregnancies (n = 319) was 0.7%. There were differences between intrahepatic cholestasis of pregnancy and non-intrahepatic cholestasis of pregnancy mothers including higher prevalence of South Asian (22.6% versus 3.1%, p < 0.001), Indigenous Australian (3.8% versus 1.8%, p < 0.05), and Asian ethnicity (8.4% versus 5.7%, p < 0.05), mothers with a body mass index >35 kg/m2 (10.6% versus 5.5%, p < 0.001), those with diabetes mellitus (25.7% versus 9.8%, p < 0.001), and those with twin births (8.7% versus 2.2%, p < 0.001). The primary clinical outcomes of intrahepatic cholestasis of pregnancy included a median gestational age at delivery of 36.4 (SE 0.09) weeks compared to 38.6 (SE 0.01) weeks (p < 0.001), a lower birth weight (3.12 (SE 0.03) versus 3.31 kg (SE 0.03), p < 0.001), and an increase in special care nursery admissions (44.5% versus 15.3%, p < 0.001). CONCLUSION: Treated intrahepatic cholestasis of pregnancy in the population described here had similar mortality outcomes although increased special care nursery admission as compared to the general population.
Entities:
Keywords:
Intrahepatic cholestasis of pregnancy; liver function tests, obstetric cholestasis, pruritus, ursodeoxycholic acid
Authors: Richard H Lee; Kay May Kwok; Sue Ingles; Melissa L Wilson; Patrick Mullin; Marc Incerpi; Bhuvan Pathak; T Murphy Goodwin Journal: Am J Perinatol Date: 2008-05-28 Impact factor: 1.862
Authors: Carsten Hagenbeck; Ulrich Pecks; Frank Lammert; Matthi As C Hütten; Felix Borgmeier; Tanja Fehm; Ekkehard Schleußner; Holger Maul; Sven Kehl; Amr Hamza; Verena Keitel Journal: Gynakologe Date: 2021-04-20