| Literature DB >> 31521441 |
Nancy Padilla-Coreano1, Sarah Canetta2, Rachel M Mikofsky3, Emily Alway3, Johannes Passecker4, Maxym V Myroshnychenko3, Alvaro L Garcia-Garcia5, Richard Warren5, Eric Teboul6, Dakota R Blackman5, Mitchell P Morton5, Sofiya Hupalo3, Kay M Tye1, Christoph Kellendonk7, David A Kupferschmidt3, Joshua A Gordon8.
Abstract
Long-range synchronization of neural oscillations correlates with distinct behaviors, yet its causal role remains unproven. In mice, tests of avoidance behavior evoke increases in theta-frequency (∼8 Hz) oscillatory synchrony between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). To test the causal role of this synchrony, we dynamically modulated vHPC-mPFC terminal activity using optogenetic stimulation. Oscillatory stimulation at 8 Hz maximally increased avoidance behavior compared to 2, 4, and 20 Hz. Moreover, avoidance behavior was selectively increased when 8-Hz stimulation was delivered in an oscillatory, but not pulsatile, manner. Furthermore, 8-Hz oscillatory stimulation enhanced vHPC-mPFC neurotransmission and entrained neural activity in the vHPC-mPFC network, resulting in increased synchrony between vHPC theta activity and mPFC spiking. These data suggest a privileged role for vHPC-mPFC theta-frequency communication in generating avoidance behavior and provide direct evidence that synchronized oscillations play a role in facilitating neural transmission and behavior. Published by Elsevier Inc.Entities:
Keywords: anxiety; avoidance; hippocampus; medial prefrontal cortex; optogenetics; oscillations; synchrony; theta
Mesh：
Year: 2019 PMID： 31521441 PMCID： PMC6842114 DOI： 10.1016/j.neuron.2019.08.006
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 18.688